Cell culture reactor

Details Cell culture reactor Cell culture reactor

1978-02-06

1980-05-06

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Apparatus

Mutation or genetic engineering apparatus

C12K 900, C12B 110

Patent

active

042018455

ABSTRACT:
A cell culture reactor is provided for the growth of cells in vitro which employs elongate, selectively permeable hollow fibers arranged in a shallow layer configuration as a matrix for cell attachment on the outer surface of the fibers, and aeration of the cells by passage through the interior of said fibers and permeation of the membrane cell. The flow path of the culture media is directed by distributor plate means substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers.

REFERENCES:
patent: 3342729 (1967-09-01), Strand
patent: 3746175 (1973-07-01), Markley
patent: 3821087 (1974-06-01), Knazek et al.
patent: 3843454 (1974-10-01), Weiss
patent: 3883393 (1975-05-01), Knazek et al.
patent: 3997396 (1976-12-01), Delente
Williams, et al., "A Hollow Filament Fabric Blood Oxygenator," Chp. 31, Proceedings of the Artificial Heart Conference, Heggeli ed., National Heart Institute, N.I.H., Bethesda, (1969), pp. 365-371.
Schratter, "Synthetic Capillaries for Cell Culture," American Laboratory, vol. 6, No. 10, (1974), pp. 33-38.
Bulletin of Amicon Corporation, "Membrane Perfusion by Artificial Capillaries," (1975), Lexington, Mass.

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