Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-12-12
2010-06-29
Leavitt, Maria (Department: 1633)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007210, C435S008000, C435S370000, C435S373000
Reexamination Certificate
active
07745120
ABSTRACT:
The present invention provides a cell-culturing model and a method for screening compounds which can be applied in treating or preventing hepatic cirrhosis. The cell culturing model comprises a population of hepatocytes and hepatic stellate cells (HSCs) derived from co-culturing, and at least one population of the cells comprises a nucleotide sequence fragment of a reporter gene and a cell specific regulatory sequence. The cell-culturing model of the present invention can be applied in high throughput screening for effective compounds of medication, and also in understanding the functional mechanism of the effective compounds.
REFERENCES:
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patent: 02/48318 (2002-06-01), None
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Gau Rung-Jiun
Hsieh Cheng-Ta
Li Pei-Shan
Li Wen-Tyng
Weng Yu-Shih
Bacon & Thomas PLLC
Industrial Technology Research Institute
Leavitt Maria
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