Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
1997-06-18
2001-09-25
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C435S252300, C536S023100, C530S350000
Reexamination Certificate
active
06294354
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to cell-calcification inhibitory proteins as well as to genes encoding such proteins.
2. Description of Related Art
Ets genes were first identified as oncogene of avian acute leukemia virus E26. Recently, the family of Ets related genes (Ets gene superfamily) has been found in a host ranging from human to Drosophila. It is believed that these genes are a transcriptional modulator which plays a basic, important role in the control of proliferation and differentiation of cells. In contrast, the biological functions of the Ets gene superfamily are hardly known.
SUMMARY OF THE INVENTION
Recently, it has been reported that the Ets related genes (erg) are specifically expressed at the sites of cartilage formation. This indicated the possibility of erg's being involved to some extent in skeleton formation at its initial stages. The present inventors, based on such findings, have accomplished the invention by introducing into osteoblasts, an erg gene derived from chickens (herein referred to as “chicken-erg gene” or “c-erg gene”) and by successfully elucidating the functions of the c-erg gene.
REFERENCES:
Y. Kato et al., “Effects of Parathyroid Hormone and Calcitonin on Alkaline Phosphatase Activity and Matrix Calcification in Rabbit Growth-Plate Chondrocyte Cultures”, Endocrinology, vol. 127, No. 1, 1990, pp. 114-118.
K. Macleod et al., “The ETS Gene Family”, Tibs 17, 1992, pp. 251-256.
Y. Higuchi et al., “ETS Related Genes (ERG) Play A Role in Skeletal Formation”, Journal of the Japan Society of Bone Metabolism, vol. 12, No. 2, 1997.
Michael Kriegler, “Gene Transfer and Expression: A Laboratory Manual”, 1991, pp. 29-56.
M. Iwamoto et al., “Retinoic Acid is a Major Regulator of Chondrocyte Maturation and Matrix Mineralization”, Microscopy Research & Technique, 1994, 28: pp. 483-491.
P. Dhordian et al., “Mesodermal Expression of the Chicken ERG Gene Associated with Precartilaginous Condensation and Cartilage Differentiation”, Mechanism of Development, 1995, 50: pp. 17-28.
S. Hughes et al., “Adaptor Plasmids Simplify the Insertion of Foreign DNA into Helper-Independent Retroviral Vectors,” Journal of Virology, Oct. 1987, pp. 3004-3012.
C. Chen et al., “High-Efficiency Transformation of Mammalian Cells by Plasmid DNA”, Molecular and Cellular Biology, Aug. 1987, pp. 2745-2752.
M. Iwamoto et al., “Expression and Role of C-MYC in Chondrocytes Undergoing Endochondral Ossification”, Journal of Biological Chemistry, May 1993, pp. 9645-9652.
L. Gerstenfeld et al., “Expression of Differentiated Function by Mineralizing Cultures of Chicken Osteoblasts”, Development Biology, 1987, pp. 49-60.
W. Potts et al., “Epitope Mapping of Monoclonal Antibodies to GAG Protein P19 of Avian Sarcoma and Leukaemia Viruses”, J. Gen. Viol., 1982, pp. 3177-3182.
Higuchi Yoshinobu
Iwamoto Masahiro
Pacifici Maurizio
Rosenbloom Joel
Carlson Karen Cochrane
Morgan & Lewis & Bockius, LLP
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