Cell binding agent conjugates of analogues and derivatives of CC

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

5303919, 4241781, 4241791, 4241811, 548420, 548427, 548430, 548433, C07K 1600, C07K 1700

Patent

active

054750920

ABSTRACT:
Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also described. These cytotoxic agents have therapeutic use because they deliver the cytotoxic drugs to a specific cell population in a targeted fashion.

REFERENCES:
patent: 4169888 (1979-10-01), Hanka et al.
patent: 4301248 (1981-11-01), Nettleton et aL.
patent: 4912227 (1990-03-01), Kelly et al.
patent: 5045451 (1991-09-01), Uhr et al.
patent: 5106951 (1992-04-01), Morgan et al.
Hermentin et al., Behring Inst. Mitt., No. 82, pp. 197-215 (1988).
Carroll and Greene, Antibodies in Radiodiagnosis and Therapy, Zalutsky (Ed.), CRC Press Boca Raton, Fla. pp. 13-43 (1989).
Pierce Catalog, pp. E10-E45 (1992).
Coulter Catalog pp. 27, 34-35 and 40-41 (1992).
Pierce Catalog, pp. E10-E15, E34, E20 and E44 (1991).
Kirkwood et al., Journal of Clinical Oncology, vol. 5, No. 8, pp. 1247-1255 (1987).
Murray et al., J. Nucl. Med, vol. 28, pp. 25-33 (1987).
Coulter Catalog, pp. 5-6, 1992.
Katsushige Gomi et al, Anticellular and Antitumor Activity of Duocarmycins Novel Antitumor Antibiotics, JPN J. Cancer Res., vol. 83, No. 1, pp. 113-120, 1992.
Franca Riganti et al, The Unique Interaction with Immunity of FCE 24517, an Antitumor Drug with a Novel Mode of Action, Int. J. Immunopharm. (United Kingdom), vol. 14, No. 2, pp. 239-251, 1992.
Chong-Soon Lee et al, Determination of the Structural Features of (+)-CC-1065 that are Responsible for Bending and Winding of DNA, Chem. Res. Toxicol. (USA), vol. 4, No. 2, pp. 203-213, 1991.
David H. Swenson et al, Evaluation of DNA binding characteristics of some CC-1065 analogs, Chem. Biol. Interact., vol. 67, No. 3-4, pp. 199-213, 1988.
Li H. Li et al, Adozelesin, a Selected Lead Among Cyclopropylpyrroloindole Analogs of the DNA-binding Antibiotic, CC-1065, Invest. New Drugs, vol. 9, No. 2, pp. 137-148, 1991.
Bruce W. Ennis et al, The EGF Receptor System as a target for Antitumor Therapy, Cancer Invest., vol. 9, No. 5, pp. 553-562, 1991.
Magda C. Gutowski et al, Epidermal Growth Factor Receptor-reactive Monoclonal Antibodies: Xenograft Antitumor Activity Alone and as Drug Immunoconjugates, Cancer Res., vol. 51, No. 20, pp. 5471-5475, 1991.
William M. Pardridge et al, Selective Transport of an Anti-transferrin Receptor Antibody Through the Blood-brain Barrier in vivo, J. Pharmacol. Exp. Ther., vol. 259, No. 1, pp. 66-70, 1991.
Boyer et al., Antibody, Immunoconjugates and Radio pharmaceuticals, vol. 1, No. 2, pp. 105-162 (1988).
Waldmann, Science vol. 252, pp. 1657-1662 (1991).
Osband et al., Immunology Today, vol. 11, No. 6, 1990 pp. 193-195.
Roitt et al., Immunology, 3rd Edition, Mosby, St. Louis, p. 17.9 (1993).
Vincent L. Reynolds et al, "The Chemistry Mechanism of Action and Biological Properties of CC-1065 A Potent Antitumor Antibiotic", Mar. 1986, pp. 319-334 (The Jour. of Antibiotics, vol. XXXIX, No. 3).
David G. Martin et al, "CC-1065 Transformations", Jun. 1985, pp. 745-752, The Journal of Antibiotics, vol. XXXVIII, No. 6.
M. A. Warpehoski et al, "Stereoelectronic Factors Influencing the Biological Activity and DNA Interaction of Synthetic Antitumor Agents Modeled on CC-1065", 1988, pp. 590-603, J. Med. Chem., 31.
Ravi V. J. Chari et al., "Immunoconjugates Containing Novel Maytansinoids: Promising Anticancer Drugs", Jan. 1, 1992, pp. 127-131, Cancer Research, 52.
Dale L. Boger et al, "A Potent, Simple Derivative of an Analog of the CC-1065 Alkylation Subunit", 1991, pp. 55-58, Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 1.
J. Patrick McGovren et al, "Preliminary Toxicity Studies with the DNA-Binding Antibiotic, CC-1065", Jan. 1984, pp. 63-70, The Journal of Antibiotics, vol. XXXVII, No. 1.
L. J. Hanka et al, "CC-1065 (NSC-298223), A New Antitumor Antibiotic Production, In Vitro Biological Activity, Microbiological Assays and Taxonomy of the Producing Microorganism", Dec. 1978 pp. 1211-1217, The Journal of Antibiotics, vol. XXXI, No. 12.
Borrebaeck, Journal of Immunological Methods, vol. 123, pp. 157-165 (1989).
Boger et al., Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 2, pp. 115-120 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell binding agent conjugates of analogues and derivatives of CC does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell binding agent conjugates of analogues and derivatives of CC, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell binding agent conjugates of analogues and derivatives of CC will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1360706

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.