Cell-based biosensor for harmful airborne agents

Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...

Reexamination Certificate

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C435S029000, C435S395000

Reexamination Certificate

active

10798986

ABSTRACT:
A method of monitoring an air atmosphere for a harmful biological or chemical agent includes providing a plurality of mammalian respiratory airway epithelial cells borne on a porous support; contacting the porous support with a cell nutrient medium and with air by positioning said porous support at an air-liquid interface between the cell nutrient liquid and the air; sampling the air atmosphere to thereby create an air flow over the air-liquid interface so that the respiratory epithelial cells borne on the porous silicone support are contacted by the sampled air; and monitoring the respiratory epithelial cells for at least one physiological parameter indicating the cells have been exposed to the harmful agent.

REFERENCES:
patent: 6270747 (2001-08-01), Nadel et al.
patent: 6541107 (2003-04-01), Zhong et al.
Romet-Haddad S. et al. Trachael Epithelium in Culture. Cell Biology and Toxicology 8(2)141-150, Jul.-Sep. 1992.
Blanquart C. et al. Primary Cultures of Tracheal Epithelial Cells for the Evaluation of Respiratory Toxicity. Toxicity in Vitro 5(5/6)499-502, 1991.
Marano F. et al. Evaluation of Toxicity of Environmental Gas Pollutants on Respiratory Epithelia. Report 1990 NTIS PB91-110841.

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