Cell attachment peptides derived from amyloid P component

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis

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623 66, 530327, A61F 202, A61K 3702

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active

050928767

ABSTRACT:
The present invention is directed to a human serum amyloid P component peptide sequence having 12 ammo acid residues and having the sequence identified as Glu-Lys-Pro-Leu-Gln-Asn-Phe-Thr-Leu-Cys-Phe-Arg. The invention is also directed to fragments of the above peptide. Two fragments useful in the present invention have the sequence Phe-Thr-Leu-Cys-Phe-Arg and Leu-Cys-Phe-Arg. The above peptides are useful for attaching cells to substrates such as ceramics, tissue culture, dishes, polymers or enamels and thus are useful as research tools for studying particular cells. The above peptides are also useful in vivo as artificial organ replacements which attach surrounding natural cells.

REFERENCES:
patent: 4504585 (1985-03-01), Reynolds
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4782014 (1988-11-01), Serban et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
Ohnishi et al., "Isolation and Characterization of the Complete Complementary and Genomic DNA Sequences of Human Serum Amyloid P Component", J. Biochem. 100, 849-858 (1986).

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