Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-29
2000-08-29
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514395, 514415, 514712, 544253, 544282, 5483064, 549362, 549469, 568 58, A61K 31505, A61K 31405, C07D23970, C07D31914, C07C31900
Patent
active
061109223
ABSTRACT:
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
REFERENCES:
Springer, T.A., 1994, Traffic Signals for Lymphocyte Recirculation and Leukocyte Emigration: The Multistep Paradigm, CELL, 76: 301-314.
Lawrence, M.B., Springer, T.A., 1991, Leukocytes' Roll on a Selectin in Physiologic Flow Rate: Distinction from and Prerequisite for Adhesion Through Integrins, CELL, 65:859-873.
Von Adrian, V., Chambers, J.D., McEnvoy, L.M. Bargatze, R.F., Arfos, K.E., Butcher, E.C., 1991, Two-Step Model of Leukocyte-Endothelial Cell Interactions in Inflammation, Proc. National Acad. Sci USA, 88:7538-7542.
Ley, K., Gaehtgens, P., Fennie, C., Singer, M.S., Lasky, L.H., Rosen, S.D., 1991, Lectin-Like Cell Adhesion Molecule 1 Mediates Rolling in Mesenteric Venules, in vivo, BLOOD, 77:2553-2555.
Higuchi, T., Stella, V., Pro-drugs as Novel Delivery Systems, vol. 14 of the A.C.S. Symposium Series, (1993).
Roche, E.B., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987.
Prescott, E., Methods in Cell Biology, vol. XIV, Academic Press, New York, NY (1976), p. 33 et seq.
Berge, S.M., et al. J. Pharmaceutical Sciences, 1977, 66:1 et seq.
Kakimoto, et al., Cell Immunol 142:326-337, 1992.
Knoerzer, et al., Toxical Pathol 25:13-19, 1997.
Schimmer, et al., J. Immunol 160: 1455-1477, 1998.
Oppenheimer-Marks, et al., J. Clin Invest 101: 1261-1272, 1998.
Wegner, et al., Science 247:456-459, 1990.
Bloemen, et al., Am J. Respir Crit Care Med 153:521-529, 1996.
Wegner, et al., Lung 170: 267-279, 1992.
Mulligan, et al., J Immunol 154:1350-1363, 1995.
Nagase, et al., Am J Respir Crit Care Med 154:504-510, 1996.
Bennet, et al., J Pharmacol Exp Ther, 280:988-1000, 1997.
Hasagawa, et al., Int Immunol, 6:831-838, 1994.
Herrold, et al., Cell Immunol, 157:489-500, 1994.
Tanaka, et al., J. Immunol, 151:5088-5095, 1993.
Kawasaki, et al., J. Immunol, 150:1074-1083, 1993.
Panes, et al., Gastroenterology, 108:1761-1769, 1995.
Hallahan, et al., Proc Natl Acad Sci USA , 94:6432-6437, 1997.
Tamiya, et al., Immunopharmacology, 29(1):53-63, 1995.
Hartman, et al., Cardiovasc Res, 30(1):47-54, 1995.
DeMeester, et al., Transplantation, 62(10): 1477-1485, 1996.
Horgan, et al., Am J Physiol, 261(5):H1578-H1584, 1991.
Bowes, et al., Exp Neurol, 119(2):215-219, 1993.
Chopp, et al., Stroke, 25(4):869-875, 1994.
Clark, et al., Neurosurg, 75(4): 623-627, 1991.
Gute, et al., Mol Cell Biochem, 179: 169-187, 1998.
Isobe, et al., Science, 255: 1125-1127, 1992.
Talento, et al., Transplantation, 55: 418-422, 1993.
Cosimi, et al., J. Immunol, 144: 4606-4612, 1990.
Nakao, et al., Muscle Nerve, 18:93-102, 1995.
Gorczynski, Wojcik, J. Immunol, 152:2011-2019, 1994.
He, et al., Opthalmol Vis Sci, 35: 3218-3225, 1994.
Zeng, et al., Transplantation, 58: 681-689, 1994.
Harning, et al., Transplantation, 52: 842-845, 1991.
Aoudjit, et al., J. Immunol, 161: 2333-2338, 1998.
Gross, et al., Science 281, 703-706, 1998.
Geldern Tom von
Link James
Liu Gang
Pei Zhonghua
Winn Martin
Abbott Laboratories
McKane Joseph
Murray Joseph
Strode Janelle D.
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