Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-03-29
1998-02-10
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530413, 530416, 530350, 530386, 53038815, G01N 3353, A23J 100, C07K 100, C07K 1600
Patent
active
057167940
ABSTRACT:
In this invention a novel antigen is provided for screening patients suspected of having celiac disease. The antigen is prepared by starting with human placenta tissue which is perfused with a herpes and collagenase buffer to obtain a signle cell suspension. This suspension is enriched to obtain an enriched protein portion and then separated out to obtain an embryonic celiac antigen (ECA). This ECA is used with serum from patients to effect binding of ECA with IgA in the serum while applying a human IgA antibody to the serum. The results are then read on a spectrophotometer to confirm or negate the presence of celiac disease.
REFERENCES:
patent: 4777127 (1988-10-01), Suni et al.
patent: 4798800 (1989-01-01), Timpl et al.
patent: 5140100 (1992-08-01), Braunstein et al.
Nelson Brett
Ralabate James J.
Smith Lynette F.
Xybernaut Corporation
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