Ceftazidime dihydrochloride formic acid solvates

Details Ceftazidime dihydrochloride formic acid solvates Ceftazidime dihydrochloride formic acid solvates

1989-02-03

1990-07-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50146

Patent

active

049436325

ABSTRACT:
The invention relates to the crystalline formic acid solvate of (6R, 7R)-7-[(Z)-2-(2-Aminothiazol-4-y1)-2-(2-carboxyprop-2-oxyimino)acetamido]- 3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate dihydrochloride (ceftazidime dihydrochloride).
The crystalline solvate is a useful intermediate in the preparation of forms of ceftazidime suitable for administration, e.g. the pentahydrate.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan
patent: 4329453 (1982-05-01), Brodie et al.
patent: 4467086 (1984-08-01), Miller
patent: 4537959 (1989-08-01), Chou
Chemical Abstracts, vol. 105, 30045x (1986).
Chemical Abstracts, vol. 109, 170117e (1988).

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