Cefpodixime proxetil

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C540S228000

Reexamination Certificate

active

07045618

ABSTRACT:
The present invention relates to an improved and cost effective process for the industrial manufacture of cefpodoxime proxetil. More specifically, the present invention relates to the preparation of cefpodoxime proxetil of high purity and yield. The process comprises a) dissolving impure cefpodoxime proxetil or adding a solution containing cefpodoxime proxetil into a polar organic solvent or mixture(s) thereof, optionally reducing the solvent by concentration, and adding into a non-polar organic solvent or mixture(s) thereof to precipitate the solid; and b) dissolving the solid obtained from the above step into water-miscible polar organic solvent, optionally reducing the solvent by concentration, adding it into water to obtain the pure cefpodoxime proxetil.

REFERENCES:
patent: 4482710 (1984-11-01), Fujimoto et al.
patent: 4486425 (1984-12-01), Nakao et al.
patent: 5461043 (1995-10-01), Fischer et al.
patent: 6639068 (2003-10-01), Lee et al.
patent: 2002/0065262 (2002-05-01), Greil et al.
patent: 2005/0020561 (2005-01-01), Kumar et al.
patent: 0 029 557 (1981-03-01), None
patent: WO 99/35149 (1999-07-01), None
patent: WO 00/66594 (2000-11-01), None
patent: WO 01/09143 (2001-02-01), None
patent: WO 01/34611 (2001-05-01), None
patent: WO 01/87893 (2001-11-01), None

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