Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-02-11
1994-10-18
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 697, 536 234, G07K 1300, C12N 1562
Patent
active
053570448
ABSTRACT:
Cecropin fusion proteins with suppressed bactericidal activity are provided. The fusion proteins of the invention provide the sequence of a cecropin and can be expressed in a cecropin-sensitive bacterium.
REFERENCES:
patent: 4332892 (1982-06-01), Ptashne et al.
patent: 4355104 (1982-10-01), Hultmark et al.
patent: 4366246 (1982-12-01), Riggs
patent: 4499188 (1985-02-01), Konrad et al.
patent: 4520016 (1985-05-01), Hultmark et al.
patent: 5028530 (1991-07-01), Lai et al.
patent: 5166321 (1992-11-01), Lai et al.
Biochem. J., 280:219-224, (1991), Anderson et al., Biologically active and amidated a cecropin produced in a baculovirus expression system from a fusion . . . .
International Search Report for PCT/US86/00131.
Supplementary European Search Report for EP 86 900 983.7 (PCT/US86/00131).
International Search Report for PCT/US88/00324.
Andreu, D. et al., "N-terminal analogues of cecropin A: synthesis, antibacterial activity, and conformational properties", Biochemistry, 24:1683-1688 (1985).
Andreu, D. et al., "Solid-phase synthesis of cecropin A and related peptides", Proc. Natl. Acad. Sci. USA, 80:6475-6479 (Nov. 1983).
Andreu, D. et al., "Synthesis analogs of cecropin A", Chemical Abstracts, 103:769, Abstract No. 123890t (1985).
Boman, H. G. and Steiner, H., "Humoral immunity in cecropia pupae", Current Topics Microbiol. Immun., 94/95:75-91, (1981), Springer-Verlag Publishers.
Casadaban, M. J., "Fusion of the Escherichia coli lac genes to the ara promoter: a general technique using bacteriophage Mu-1 insertions", Proc. Natl. Acad. Sci. USA, 72(3):809-813 (Mar. 1975).
Clarke, P. et al., "The nucleotide sequence of the araC regulatory gene in Salmonella typhimurium LT2", Gene, 18:157-163 (1982).
DeGrado, W. F., "Solution phase synthesis of cecropin A 1-22 and potent analogs thereof using segments prepared on an oxime solid phase support", Chemical Abstracts, 101:742, Abstract No. 171691j (1984).
Gibbs, J. B. et al., "Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules", Proc. Natl. Acad. Sci. USA, 81:5704-5708 (Sep. 1984).
Greenfield, L. et al., "DNA sequence of the araBAD promoter in Escherichia coli B/r", Proc. Natl. Acad. Sci. USA, 75(10):4724-4728 (Oct. 1978).
Hedge, P. J. and Spratt, B. G., "A gene fusion that localises the penicillin-binding domain of penicillin-binding protein 3 of Escherichia coli", FEBS Lett., 176(1):179-184 (Oct. 1984).
Heusterspreute, M. et al., "Expression of galactokinase as a fusion protein in Escherichia coli and Saccharomyces cerevisiae", DNA, 3(5):377-386 (1984).
Horwitz, A. H. et al., "Construction of pBR 322-ara hybrid plasmids by in vivo recombination", Molec. Gen. Genet., 179:615-625 (1980).
Horwitz, A. H. et al., "DNA sequence of the araBAD-araC controlling region in Salmonella typhimurium LT2", Gene, 14:309-319 (1981).
Hultmark, D. et al., "Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from cecropia pupae", Eur. J. Biochem., 127:207-217 (1982).
Hurt, E. C. et al., "The amino-terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix", EMBO J., 3(13):3149-3156 (1984).
Johnston, S. et al., "High-level expression of M13 gene II protein from an inducible polycistronic messenger RNA", Gene, 34:137-145 (1985).
Kaplan, D. A. et al., "Hydrid plasmids containing the araBAD genes of Escherichia coli B/r", Gene, 3:177-189 (1978).
Kempe, T. et al., "Multiple-copy genes: production and modification of monomeric peptides from large multimeric fusion proteins", Gene, 39:239-245 (1985).
Kempe, T. et al., "Production and characterization of growth hormone releasing factor analogs through recombinant DNA and chemical techniques", BioTechnology, 4:565-568 (1986).
Kuhn, A. et al., "Isolation of mutants in M13 coat protein that affect its synthesis, processing, and assembly into phage", J. Biol. Chem., 260(29):15907-15913 (Dec. 15, 1985).
Lee, J.-H. et al., "Isolation of ara-lac gene fusions in Salmonella typhimurium LT2 by using transducing bacteriophage Mu d(AP.sup.r lac)", J. Bacteriol., 143(3):1325-1331 (Sep. 1980).
Lewin, B., "Operon control circuits", In: Gene Expression-1, pp. 323-328, John Wiley & Sons (1982).
Lin, H.-C. et al., "The araBAD operon of Salmonella typhimurium LT2", Gene, 34:111-122 (1985).
Merrifield, R. B. et al., "Synthesis of the antibacterial peptide cecropin A(1-33)", Biochemistry, 21:5020-5031 (1982).
Miyada, C. G. et al., "Five mutations in the promoter region of araBAD operon of Escherichia coli B/r", J. Bacteriol., 156(2):765-772 (Nov. 1983).
Qu, X. et al., "Insect immunity: isolation and structure of cecropins B and D from pupae of the Chinese oak silk moth, Antheraea pernyi", Eur. J. Biochem., 127:219-224 (1982).
Reiss, B. et al., "Protein fusions with the kanamycin resistance gene from transposen Tn5", EMBO J., 3(13):3317-3322 (1984).
Ruther, U. and Muller-Hill, B., "Easy identification of cDNA clones", EMBO J., 2(10):1791-1794 (1983).
Schleif, R. Greenblatt, J. and Davis, R. W., "Dual control of arabinose genes on transducing phase .lambda.dara", J. Mol. Biol., 59:127-150 (1971).
Schleif, R. and Greenblatt, J., "Transcription in the lambda-ara phage", Cold Spring Harbor Symp. Quant. Biol., 35:369-373 (1970).
Steiner, H. et al., "Sequence and specificity of two antibacterial proteins involved in insect immunity", Nature, 292:246-248 (Jul. 16, 1981).
Steiner, H., "Secondary structure of the cecropins: antibacterial peptides from the moth Hyalophora cecropia", FEBS Lett., 137(2):283-287 (Jan. 1982).
van Hofsten, P. et al., "Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B from Hyalophora cecropia", Proc. Natl. Acad. Sci. USA, 82:2240-2243 (Apr. 1985).
van Hofsten, P. et al., "Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B from Hyalophora cecropia", Chemical Abstracts, 103:127-128, Abstract No. 48969v (1985).
Wilcox, G. et al., "DNA sequence analysis of mutants in the araBAD and araC promoters", In: Promoters: Structure and Function, pp. 183-194, Rodriguez and Chamberlin, eds., Praeger (1982).
Lai Jiunu
Lee Jar-How
Lin Yun-Long
Ray Dan S.
Wilcox Gary
Hill Jr. Robert J.
Ulm John D.
Xoma Corporation
LandOfFree
Cecropins fusion proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cecropins fusion proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cecropins fusion proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2373985