Cecropin polypetides with activity against Gram-positive and Gra

Details Cecropin polypetides with activity against Gram-positive and Gra Cecropin polypetides with activity against Gram-positive and Gra

1987-02-06

1992-11-24

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530332, 530345, 530858, 435 691, C07K 710

Patent

active

051663210

ABSTRACT:
The invention relates to cecropin-like polypeptides with a variey of C-terminus modifications. Conversion of the terminal carboxy group to a homoserine extended neutral, negatively charged or positively charged form results in the polypeptides of the invention that have significant bactericidal effects against both Gram-positive and Gram-negative bacteria.

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