CEA-binding protein and uses thereof

Details CEA-binding protein and uses thereof CEA-binding protein and uses thereof

1991-05-31

1994-01-25

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424 9, 436 64, 436503, 436543, 436813, 5303877, 53038825, 5303893, 530828, A61K 4900, C07K 1506, C07K 1514, G01N 3350

Patent

active

052816974

ABSTRACT:
Disclosed is a protein that specifically binds carcinoembryonic actigen (CEA) in the presence of divalent cation in vitro. This protein has a molecular weight of about 20 kD as determined by SDS-polyacrylamide gel electrophoresis, is glycosylated, and includes the amino acid sequence set forth in the Sequence Listing as SEQ ID NO:4. Also disclosed are antibodies that recognize the CEA binding protein, methods of detecting carcinoma, methods of treating carcinoma, and a kit for screening a patient for carcinoma.

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