Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-10-05
1999-02-23
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038885, 5303888, 5303917, 5303913, 536 2353, 435328, 435 697, 4353201, 424 149, 4241781, 4241811, C07K 1646, C12N 1513, C07H 2104
Patent
active
058745408
ABSTRACT:
A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less immunogenic in a heterologous host than, the parental murine monoclonal antibody A preferred murine Class III, anti-CEA monoclonal antibody is the MN-14 antibody and the preferred heterologous antibody is from a human. Also provided are DNA constructs and vectors for producing the humanized monoclonal antibodies, and diagnostic and therapeutic conjugates using same.
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Primus et al., "Immunological Heterogeneity of Carcinoembryonic . . . ", Cancer Research, 43:686-92, Feb. 1983.
Hansen et al., "Characterization of Second-Generation Monoclonal . . . ", Cancer, 71(11):3478-85, Jun. 1993.
Losman et al., "Mimicry of a Carcinoembryonic Antigen Epitope . . . ", Int. J. Cancer, 56:580-84, 1994.
Armour Kathryn L.
Hansen Hans J.
Eisenschenk Frank C.
Immunomedics Inc.
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