Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-06-26
2007-06-26
Helms, Larry R. (Department: 1643)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S091100, C435S242000, C435S242000, C435S252300, C435S320100, C435S242000, C530S387100, C530S387300, C530S388200, C530S388750, C424S133100, C424S143100, C424S131100, C424S130100, C424S141100
Reexamination Certificate
active
10313392
ABSTRACT:
The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants and are thus useful in the treatment and prophylaxis of human thrombotic disease. The invention also provides methods of making the CDR-grafted antibodies and pharmaceutical compositions for the attenuation or prevention of coagulation.
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Joliffe Linda K.
Pulito Virginia L.
Zivin Robert A.
Dow Kenneth J.
Helms Larry R.
Ortho-McNeil Pharmaceutical , Inc.
Tungaturthi Parithosh K.
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