Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-24
1999-03-02
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
536 2353, 5303888, C07K 1900, C07K 1630
Patent
active
058772936
ABSTRACT:
The present invention provides humanized antibody molecules (HAMs) having specificity for carcinoembryonic antigen (CEA) and having an antigen binding site wherein at least one of the complementarity determining regions (CDRs) of the variable domains is derived from the mouse monoclonal antibody A5B7 (A5B7 MAB) and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin. The HAMs may be chimeric humanized antibodies or CDR-grafted humanized antibodies and are preferably produced by recombinant DNA techniques. The HAMs are useful for in vivo diagnosis and therapy.
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patent: 5530101 (1996-06-01), Queen et al.
Washington Post "Colon Cancer Test Found To Be Flawed" Aug. 25, 1993.
Curti: Crit. Rev. Onc/Hemat. 14:29-39 1993.
Queen et al PNAS 86:10029-10033 1989.
Biechmann et al Nature 332:323-327 1988.
HAMS TibTech 11:42-44 1993.
Waldmann Science 252:1657-1662 1991.
Adair John Robert
Bodmer Mark William
Mountain Andrew
Owens Raymond John
Celltech Therapeutics Limited
Eisenschenk Frank C.
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