CDNAS encoding mouse and rat type-2 angiotensin II receptors and

Details CDNAS encoding mouse and rat type-2 angiotensin II receptors and CDNAS encoding mouse and rat type-2 angiotensin II receptors and

1993-11-05

1996-09-17

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 235, 4353201, 4352523, 43525411, 435 691, C12N 1512, C12N 1563, C12N 510, C12N 121

Patent

active

055567800

ABSTRACT:
An angiotensin II type 2 receptor (AT.sub.2 receptor), structurally related cell receptors, nucleic acids encoding such AT.sub.2 receptors, AT.sub.2 receptor-related peptides, and methods of using AT.sub.2 receptors and AT.sub.2 receptor-encoding nucleic acids are provide. AT.sub.2 receptor-specific binding compounds are disclosed including antibodies to AT.sub.2 receptor epitopes. The invention provides AT.sub.2 receptor-based pharmaceutical compositions and AT.sub.2 receptor-based methods rot screening chemical libraries for regulators of cell growth/differentiation. In particular, the invention provides methods for identifying agonists and antagonists of the disclosed AT.sub.2 receptor. Such compositions find broad utility in the treatment of cardiovascular disease, cancer, reproductive disease, etc.

REFERENCES:
Nakajima et al., (1993) Biochem. Biophys. Res. Comm. 197(2): 393-99.
Grady et al. (1991) J. Clin. Invest. 88: 921-33.
Whitebread et al. (1991) Biochem. Biophys. Res. Comm. 181: 1365-71.
Gearing et al. (1989) EMBO J. 8: 3667-76.
J uppner et al. (1991) Science 254: 1024-26.
Mukoyama et al., GenBank database record, accession no. U01908.
Kambayashi et al., GenBank database record, accession no. D16840.
Ichiki et al., GenBank database record, accession no. U00768.

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