cDNA probes and antibodies for human methenyltetrahydrofolate sy

Details cDNA probes and antibodies for human methenyltetrahydrofolate sy cDNA probes and antibodies for human methenyltetrahydrofolate sy

1995-01-19

1997-05-20

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 241, 536 243, 536 2431, 536 232, 935 14, 935 78, C12N 1511, C12N 1512, C12N 1552, C12Q 168

Patent

active

056311311

ABSTRACT:
The present invention relates to a cDNA probe for the detection of the mRNA for human methenyltetrahydrofolate synthetase, which comprises the nucleic acid sequence as shown in FIG. 6 or any functional analogs thereof wherein the hybridization of the probe and the mRNA for human methenyltetrahydrofolate synthetase is substantially preserved. The present invention also relates to a polyclonal antibody or an antigen-binding fragment thereof for the detection of the mRNA for human methenyltetrahydrofolate synthetase, wherein said antibody is raised against a protein segment aa.sup.100-112 H-Phe-Asp-Lys-His-Gly-Asn-Arg-Leu-Gly-Lys-OH of human methenyltetrahydrofolate synthetase.

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