cDNA of dock 180 gene and dock180 protein

Details cDNA of dock 180 gene and dock180 protein cDNA of dock 180 gene and dock180 protein

1997-11-17

1998-07-28

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303881, 530350, 530300, 536 231, 536 235, C07K 1600

Patent

active

057864535

ABSTRACT:
The present invention provides a cDNA of DOCK180 gene, which has a nucleotide sequence of SEQ ID No: 1 and of which translation product binds to the proto-oncogene product CRK, a recombinant vector containing this cDNA, a DOCK180 protein expressed from the cDNA which has a amino acid sequence of SEQ ID No: 2, and an antibody to the DOCK180 protein. According to the present invention, It is possible to develop new diagnosing and therapeutic techniques using DOCK180 protein and antibody against the protein.

REFERENCES:
Takai et al. (1996) 35:403-404.
Erikson et al. (1997) 138:585-603.
Matsuda et al. (1996) 8:335-340.
H. Hasegawa et al. "DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane", Molecular and Cellular Biology, vol. 16, pp. 1770-1776, Apr. 1996.
M. Matsuda et al., "Interaction Between the Amino-Terminal SH3 Domain of CRK and Its Natural Target Proteins", The Journal of Biological Chemistry, vol. 271, No. 24, pp. 14468-14472, 1996.

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