cDNA encoding the long isoform of the D.sub.2 dopamine receptor

Details cDNA encoding the long isoform of the D.sub.2 dopamine receptor cDNA encoding the long isoform of the D.sub.2 dopamine receptor

1993-08-03

1996-09-03

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

G01N 33567

Patent

active

055522890

ABSTRACT:
In the present investigation, we report the identification and cloning of a cDNA encoding an RNA splice variant of the rat D.sub.2 receptor CDNA.sup.12. This cDNA codes for a receptor isoform which is predominantly expressed in the brain and contains an additional 29 amino acids in the 3rd cytoplasmic loop, a region believed to be involved with G protein coupling. This is the first example of a novel G-protein coupled receptor isoform generated by alternative RNA splicing.

REFERENCES:
Ohara, et al.; The Interaction Between D-2 Dopamine Receptors and GTP-Binding Proteins; Molecular Pharmacology; vol. 33, pp. 290-296; 1988.
Bunzow, et. al. "Cloning and Expression Of A Rat D.sub.2 Dopamine Receptor cDNA." Nature, vol. 336, pp. 783-787, 22/29 Dec. 1988.

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