cDNA encoding the long isoform of the D.sub.2 dopamine receptor

Details cDNA encoding the long isoform of the D.sub.2 dopamine receptor cDNA encoding the long isoform of the D.sub.2 dopamine receptor

1989-11-01

1992-07-07

Doll, John

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

536 27, C12N 1512, C07H 2104

Patent

active

051282542

ABSTRACT:
In the present investigation, we report the identification and cloning of a cDNA encoding an RNA splice variant of the rat D.sub.2 receptor cDNA.sup.12. This cDNA codes for a receptor isoform which is predominantly expressed in the brain and contains an additional 29 amino acids in the 3rd cytoplasmic loop, a region believed to be involved with G protein coupling. This is the first example of a novel G-protein coupled receptor isoform generated by alternative RNA splicing.

REFERENCES:
Bunzow, et al., Cloning and Expression of a Rat D.sub.2 Dopamine Receptor cDNA, Nature, vol. 336, pp. 783-787, Dec. 22/29, 1988.
Elazar, et al., Association of Two Pertussis Toxin-Sensitive G-Proteins with the D.sub.2 -Dopamine Receptor from Bovine Striatum, EMBO Journal, vol. 8, No. 8, pp. 2353-2357, 1989.
Mitsuhashi, et al., Regulation of Expression of the Alternative mRNAs of the Rat .alpha.-Thyroid Hormone Receptor Gene, J. Biological Chemistry, vol. 264, No. 15, pp. 8900-8904; May 25, 1989.

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