Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-02-13
2000-11-28
Ulm, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352523, 4353201, C12N 1512
Patent
active
061537403
ABSTRACT:
The invention features a method for identifying compositions which modulate the activity of a Na.sup.+ -dependent nucleoside transport polypeptide. This invention also features isolated DNA encoding the transport polypeptide, a method for recombinantly producing the transport polypeptide, antibodies which specifically bind to the polypeptide and polynucleotide sequences which specifically hybridize to polynucleotide encoding the transport polypeptide.
REFERENCES:
Huang et al., "Cloning and Functional Expression of a Complementary DNA Encoding a Mammalian Nucleoside Transport Protein", The Journal of Biological Chemistry, vol. 269, No. 27, Jul. 8, 1994 pp. 17757-17760.
Birnbaum et al. "Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein", P.N.A.S. 83:5784-5788, Aug. 1986.
Ramamoorthy et al. "Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization". P.N.A.S. 90:2542-2546, Mar. 1993.
Nelson et al. "Cloning of the human brain GABA transporter". FEBS Letters 269(1):181-184, Aug. 1990.
Bannon et al. "Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age". P.N.A.S. 89:7095-7099, Aug. 1992.
Jhiang et al. "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Letters 318(2):139-144, Mar. 1993.
Shashidharan et al. "Cloning and characterization of a glutamate transporter cDNA from human cerebellum". Bioch. et Biophys. acta 1216:161-164, Oct. 1993.
Kim et al. "Cloning of the Humen Glycine Transporter Type 1: Molecular and Pharmacological Characterizatyon of Novel Isoform Variants and Chromosomal Localization of the Gene in the Human and Mouse Genomes". Mol. Pharmocol. 45:608-617, Apr. 1994.
Cass Carol E.
Young James D.
Ulm John
University of Alberta
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