cDNA encoding human phospholipase A.sub.2 polypeptide

Details cDNA encoding human phospholipase A.sub.2 polypeptide cDNA encoding human phospholipase A.sub.2 polypeptide

1992-04-30

1994-01-18

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351723, 43525231, 43525233, 4352523, 43525411, 4353201, 536 232, C12N 510, C12N 121, C12N 119, C12N 1585

Patent

active

052799573

ABSTRACT:
The present invention provides a novel human polypeptide having phospholipase A.sub.2 activity, referred to as PLA.sub.2 (Ca.sup.-). The invention also provides nucleic acid sequences coding for the novel polypeptide, expression vectors comprising the nucleic acid sequences coding for the novel polypeptide, host cells and cell cultures capable of expressing the novel polypeptide. The present invention further provides antisense oligonucleotides for modulation of expression of the gene coding for the novel polypeptide. Assays for screening test compounds for their ability to inhibit phospholipase A.sub.2 activity are also provided.

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