cDNA encoding a vesicle transport protein

Details cDNA encoding a vesicle transport protein cDNA encoding a vesicle transport protein

1997-07-25

1998-11-24

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 43525233, 4353201, 435325, 536 231, 536 235, C12N 1500, C12N 1563, C12N 1585, C07H 2104

Patent

active

058405372

ABSTRACT:
The invention provides a human vesicle transport protein (NVTP-1) and polynucleotides which identify and encode NVTP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NVTP-1.

REFERENCES:
Abe, T. GenBank. Accession # AB002559, Apr. 4, 1997.
Rothman, J.E., et al., "Protein Sorting by Transport Vesicles", Science, 272:227-234 (1996). (GI 642025) (GI 642026).
Tellam, J.T., et al., "Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 270:5857-5863 (1995).
Hata, Y., et al., "A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins", Journal of Biological Chemistry, 270:13022-13028 (1995).
Katagiri, H., et al., "A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Sec1 Expressed Ubiquitously in Mammalian Cells", Journal of Biological Chemistry, 270:4963-4966 (1995).
Fujita, Y., et al., "Phosphorylation on Munc-18
-Sec1/rbSec1 by Protein Kinase C", Journal Biological Chemistry, 271:7265-7268 (1996).
Tellam, J.T., et al.,(GI 642025) GenBank Sequence Database (Accession U19520), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 642026).
Riento, K., et al., (GI 1246216) GenBank Sequence Database (Accession L41609), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1246217).
Veerasamy, R., et al., "Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 271:13300-13303 (1996).
Ziegler, S.F., et al., (GI 1480868) GenBank Sequence Database ( Accession U63533), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1480869).

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