CDNA encoding a novel human protein tyrosine phosphatase

Details CDNA encoding a novel human protein tyrosine phosphatase CDNA encoding a novel human protein tyrosine phosphatase

1994-12-01

1997-08-19

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435193, 4352523, 43525411, 4353201, 435357, 435358, 435367, 435369, 435325, 536 232, C12N 1512

Patent

active

056587562

ABSTRACT:
A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.

REFERENCES:
Mizuno et al., FEB Letters, vol. 355, 223-228, 1994.
Krueger et al., Proc. Natl. Acad. Sci, vol. 89, 7417-7421, 1992.
Lau, K.H. William et al., Purification and Characterization of an Acid Phosphatase that Displays Phosphotyrosy-protein . . . , Jorn. of Biol. Chem., vol. 262, No. 3, pp. 1389-1397 (1987).
Yan, Hai et al., A Novel Receptor Tyrosine Phosphatase-.delta.That is Highly Expressed in the Nervous System, Jorn. of Biol. Chem., vol. 268, pp. 24880-24886 (1993).
Lau, K.H. William, et al., Phosphotyrosyl protein phosphatases, Biochem. J., vol. 257, pp. 23-36, (1989).
Hashimoto, Naotake, et al., Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine . . . , Biochem J., vol. 284, pp. 569-576 (1992).
Krueger and Saito, A Human transmembrane protein-tyrosine-phosphatase, PTP is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases, Proc. Natl. Acad. Sci., vol. 89, pp. 7417-7421 (1992).
Chernoff, Jonathan et al., Cloning of a cDNA for a major human protein-tyrosine-phosphatase, Proc. Nat'l. Acad. Sci., vol. 87, pp. 2735-2739 (1990).
Kaplan, R., et al., Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain, Proc. Natl. Acad. Sci., vol. 87, pp. 7000-7004 (1990).
Wergedal and Lau, Human Bone Cells Contain a Flouride Sensitive Acid Phosphatase: Evidence that this enzyme functions at neutral pH as a phosphotyrosyl Protein phosphatase, Clin. Biochem, vol. 25, pp. 47-53 (1992).
Yi, Taolin et al., Identification of Novel Protein Tyrosine Phosphatases of Hematopoietic Cells by Polymerase Chain Reaction Amplification, Blood, vol. 78, No. 9, pp. 2222-2228 (1991).

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