Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2011-08-09
2011-08-09
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C435S440000, C424S093100, C424S093200, C424S093600, C424S199100, C424S204100, C424S211100, C424S212100
Reexamination Certificate
active
07993924
ABSTRACT:
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
REFERENCES:
patent: 5166057 (1992-11-01), Palese et al.
patent: 5240703 (1993-08-01), Cochran
patent: 5840520 (1998-11-01), Clarke et al.
patent: 6033886 (2000-03-01), Conzelmann
patent: 2007/0280961 (2007-12-01), Billeter et al.
patent: 2035386 (1991-08-01), None
patent: 2065245 (2002-11-01), None
patent: 2154023 (2007-04-01), None
patent: 0440 219 (1991-08-01), None
patent: 0702085 (1996-03-01), None
patent: WO 95/03070 (1995-02-01), None
patent: WO 96/34625 (1996-11-01), None
Caignard, Grégory, et al., “Measles Virus V Protein Blocks Jak1-Mediated Phsphorylation of STAT1 to Escape IFN-α/β Signaling,” Virology, vol. 368, 2007, pp. 351-362.
Combredet, Chantal, et al., “A Molecularly Cloned Schwarz Strain of Measles Virus Vaccine Induces Strong Immune Responses in Macaques and Transgenic Mice,” Journal of Virology, vol. 77, No. 21, 2003, pp. 11546-11554.
Devaux, Patricia, et al., “Tyrosine 110 in the Measles Virus Phosphoprotein is Required to Block STAT1 Phosphorylation,” Virology, 2006, pp. 1-12.
Fields, Bernard N., ed. et al., “Paramyxoviridae: The Viruses and Their Replication,” Virology, third edition, 1996, pp. 1197 and 1294.
Ohno, Shinji, et al., “Dissection of Measles Virus V Protein in Relation to its Ability to Block Alpha/Beta Interferon Signal Transduction,” Journal of General Virology, vol. 85, 2004, pp. 2991-2999.
Reyes del Valle, Jorge, et al., “A Vectored Measles Virus Induces Hepatitis B Surface Antigen Antibodies While Protecting Macaques Against Measles Virus Challenge,” Journal of Virology,vol. 81, No. 19, 2007, pp. 10597-10605.
“Transfection,” Wikipedia, from the World Wide Web, <http://fr.wikipedia.org/wiki/transfection>. (2008).
Ballart, et al., “Infectious measles virus from cloned cDNA”, EMBO J., pp. 379-384, (1990).
Ballart, et al., Retraction “Infectious measles virus from cloned cDNA,” 10(11), p. 3558 (1991).
Baltimore et al., “Ribonucleic Acid Synthesis of Vesicular Stomatitis Virus, II. An RNA Polymerase in the Virion,” 1970, Proc. Natl. Acd. Sci. 66(2):572-576.
Baron, et al., “Rescue of Rinderpest Virus from Cloned cDNA,” J. Virol, vol. 71, pp. 1265-1271 (1997).
Bricker et al., “Monoclonal Antibodies to the Glycoprotein of Vesicular Stomatitis Virus (New Jersey Serotype): A Method for Preliminary Mapping of Epitopes”, 1987, Virology 161:533-540.
Calain, P., et al., “Molecular Cloning of natural Paramyxovirus copy-back defective interfering RNAs and their expression from DNA,” Virology, 191:62-71 (1992).
Calain, P., et al., “The rule of six, a basic feature for efficient replication of sendai virus defective interfering RNA,” Journal of Virology, vol. 67, No. 8, pp. 4822-4830 (1993).
Collins et al., “Rescue of a 7502-Nucleotide (49.3% of Full-Length) Synthetic Analog of Respiratory Syncytial Virus Genomic RNA”, 1993, Virology 195: 252-256 (1993).
Collins et al., “Rescue of synthetic analogs of respiratory syncytial virus genomic RNA and effect of truncations and mutations on the expression of a foreign reporter gene”, Proc. Natl. Acad. Sci. 88:9663-9667 (1991).
Collins, et al., “Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development,” Proc. Natl. Acad. Sci., vol. 92, pp. 11563-11567 (1995).
Conzelmann et al., “Rescure of Synthetic Genomic RNA Analogs of Rabies Virus by Plasmid-Encoded Proteins”, 1994, J. Virol. 68(2):713-719.
Das, et al., “Improved technique for transient expression and negative strand virus rescue using fowlpox T7 recombinant virus in mammalian cells”, J. Virol. Methods vol. 89, pp. 119-127 (2000).
De et al., Rescure of Synthetic Analogs of Genome RNA of Human Parainfluenza Virus Type 3, 1993, Virology 196:344-348.
Deng, et al., “High-efficiency protein synthesis from T7 RNA polymerase transcripts in 3T3 fibroblasts,” (1991), Gene, vol. 109, pp. 193-201.
Dimock et al., “Rescue of Synthetic Analogs of Genomic RNA and Replicative-Intermediate RNA of Human Parainfluenza Virus Type 3”, 1993, J. Virol. 67(5):2772-2778.
Dorland's Illustrated Medical Dictionary, 30th Edition, Saunders and Company, pp. 565 and 1414, (2003).
Eck, et al., “Gene-Based Therapy,” Goodman & Gilman's the Pharmacological Basis of Therapeutics, 9th Edition, Chapter 5, (1996).
Elroy-Stein, et al., “Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells,” Proc. Natl. Acad. Sci., (Sep. 1990), vol. 87, pp. 6743-6747.
Enami et al., “Introduction of site-specific mutations into the genome of influenza virus,” 1990, Proc. Natl. Acd. Sci. 87:3802-3805.
Enami, M., et al., “A measles virus subgenomic RNA: Structure and generation mechanism,” Virology 171: 427-433 (1989).
Engelhorn, M., et al., “Molecular Cloning and Characterization of a Sendai virus internal delection of defective RNA,” Journal of General Virology, 74:137-141 (1993).
Fuerst et al., “Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase”, 1986, Proc. Natl. Acad. Sci. 83:8122-8126.
Gallione et al., “Nucleotide Sequence of a cDNA Clone Encoding the Entire Glycoprotein from the New Jersey Serotype of Vesicular Stomatitis Virus”, 1983, J. Virol. 46(1): 162-169.
Gallione et al., “Nucleotide Sequences of the mRNA's Encoding the Vesicular Stomatitis Virus N and NS Proteins”, 1981, J. Virol. 39(2):529-535.
Garcin, et al., “A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy-back nondefective interfering virus,” EMBO, (1995) vol. 14, No. 24, pp. 6087-6094.
Ghattas, et al., “The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos,” Mol. and Cell Biology, vol. 11, pp. 5848-5859 (1991).
Harty, R.N., et al., “Mutations within noncoding terminal sequences of model RNAs of Sendai virus: Influence on reporter gene expression,” Journal of Virology,69(8):5128-5131 (1995).
He, et al., “Recovery of Infectious SV5 from Cloned DNA and Expression of a Foreign Gene,” Virology vol. 237, pp. 249-260 (1997).
Hoffman, et al., “An Infectious Clone of Human Parainfluenza Virus Type 3”, J. Virol, vol. 71, pp. 4272-4277 (1997).
Kato, et al., “Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense”, Genes to Cells 1569-1579 (1996).
Kolakofsky, et al., “Paramyxovirus RNA Synthesis and the Requirement for Hexamer Genome Length: The Rule of Six Revisited,” J. Virol, 72(2), pp. 891-899, (1998).
Kurath et al., “Molecular Cloning of the Six mRNA Species of Infectious Hematopoietic Necrosis Virus, a Fish Rhabdovirus, and Gene order Determination by R-Loop Mapping”, 1985, J. Virol. 53(2):469-476.
Lawson, et al., “Recombinant vesicular stomatitis viruses from DNA
Billeter Martin A.
Kälin Karin
Radecke Frank
Schneider Henriette
Spielhofer Pius
Crucell Switzerland AG
Falk Anne-Marie
McDonnell Boehnen & Hulbert & Berghoff LLP
LandOfFree
cDNA corresponding to the antigenome of nonsegmented... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with cDNA corresponding to the antigenome of nonsegmented..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and cDNA corresponding to the antigenome of nonsegmented... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2661093