CDNA collections encoding proteins regulated during programmed c

Details CDNA collections encoding proteins regulated during programmed c CDNA collections encoding proteins regulated during programmed c

1997-09-08

1999-07-27

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 536 2431, C12Q 168, C12N 1512, C07H 2100

Patent

active

059288710

ABSTRACT:
The present invention identifies cDNA collections enriched in genes regulated in prostate homeostasis, prostate regression, and in genes regulated in programmed cell death. These novel cDNA collections provide cDNAs that encode proteins that are either unique to general programmed cell death or unique to prostate regression. These transcripts can be used as markers to screen, monitor and/or to diagnose diseased conditions including prostate cancer. In addition, these cDNA collections can be used in methods of designing novel therapeutic agents useful for treating prostate cancer. Methods of making these collections through subtraction hybridization are described.

REFERENCES:
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Leger et al., Biochem. Biophy. Res. Comm. 147:196-203 (1987).
Wang et al. (1993) J. Biol. Chem. 268:16270-8.
Shaw et al. (1988) Cloning and sequencing of cDNA encoding a rat salivary cysteine proteinase inhibitor inducible by beta-adrenergic agonists. J. Biol. Chem. 263:18133-18137, Dec. 1988.
Wodnar-Filipowicz et al. (1984) Cloning and sequence analysis of cDNA for rat spleen thymosin beta 4. Proc. Natl. Acad. Sci. USA 81:2295-2297, Apr. 1984.

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