CDNA collections encoding proteins regulated during programmed c

Details CDNA collections encoding proteins regulated during programmed c CDNA collections encoding proteins regulated during programmed c

1996-11-18

1998-10-13

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, C07H 2104

Patent

active

058213520

ABSTRACT:
The present invention identifies cDNA collections enriched in genes regulated in prostate homeostasis, prostate regression, and in genes regulated in programmed cell death. These novel cDNA collections provide cDNAs that encode proteins that are either unique to general programmed cell death or unique to prostate regression. These transcripts can be used as markers to monitor and/or to diagnose diseased conditions. Methods of making these collections through subtraction hybridization are described.

REFERENCES:
patent: 5525471 (1996-06-01), Zeng
Leger et al., Biochem. Biophy. Res Comm. 147:196-203 (1987).
Briehl et al. (1991) Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate, Mol. Endocrinol. 5:1381-1388. , Oct. 1991.
Wang et al. (1993) Thyroid hormone-induced gene expression program for amphibian tail resorption. J. Biol. Chem. 268:16270-16278, May. 1993.

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