cDNA clones coding for polypeptides exhibiting multi-lineage cel

Details cDNA clones coding for polypeptides exhibiting multi-lineage cel cDNA clones coding for polypeptides exhibiting multi-lineage cel

1984-03-19

1987-09-22

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435240, 435255, 4351723, 435317, 536 27, 935 48, 935 49, 935 50, 935 69, 935 70, 935 71, 935 13, 935 47, 435320, 43524026, 4352401, C12P 2100, C07H 1512, C12N 1500, C12N 100

Patent

active

046955429

ABSTRACT:
Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian multi-lineage growth cell activity. One of these polypeptides is 166 amino acids in length, including a potential leader sequence of about 19 amino acids. The cDNA is derived from messenger RNA isolated from a mouse T-cell line after activation with concanavalin A. The cDNA was cloned by incorporation into a plasmid vector, which was then transformed into E. coli. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA after transfection into a mammalian host cell, such as monkey COS-7 cells.

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