Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-03-16
1988-07-19
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4352402, 435320, 4351723, 435 70, 536 27, 935 11, 935 32, 935 70, C12P 2100, C12P 2102, C12N 1500, C12N 500, C12N 100, C07H 1700
Patent
active
047585110
ABSTRACT:
Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian IgE binding factor activity. One of these clones contains an open reading frame consisting of 556 codons. The cDNA is derived from messenger RNA isolated from a rat/mouse T-cell hybridoma line. The cDNA was cloned by incorporation into a pcD plasmid vector. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA to form a polypeptide having IgE potentiating activity after transfection into a mammalian host cell, such as monkey Cos7 cells.
REFERENCES:
Huff, T. et al, J. Immunol., vol. 129, No. 2, pp. 509-514, 1982.
Martens, C. et al., Proc. Natl. Acad. Sci., vol. 82, pp. 2460-2464, 1985.
Okayama, H. et al., Molec. and Cell Biol., vol. 3, No. 2, pp. 280-289, 19 3.
Elder, J. T. et al., Ann. Rev. Genet., vol. 15, pp. 295-340, 1981.
Moriarty, A. et al., Proc. Natl. Acad. Sci., vol. 78, No. 4, pp. 2606-2610, 1981.
Huff Thomas F.
Ishizaka Kimishige
Martens Christine L.
Moore Kevin W.
DNAX Research Institute of Molecular and Cellular Biology, Inc.
Huleatt Jayme A.
Macevicz Stephen C.
Smith William M.
The Johns Hopkins University
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