Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1991-10-24
1996-09-03
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 691, 4352523, 4353201, 536 235, C12N 1512
Patent
active
055523080
ABSTRACT:
The invention described in this disclosure relates to a cloned cDNA encoding the serotonin transporter protein (5HTT) usually found in cells of part of the central nervous system, gut, adrenal gland and in platelets. The invention is further directed to the purified serotonin transporter protein and its use and immunogen for the production of anti-5HTT antibodies. The disclosure also discussses methods for use of the cDNA for diagnostic and treatment applications, and methods for use of permanent cell lines transformed with the serotonin transporter cDNA for pharmaceutical screening. The use of anti-5HTT antibodies as a diagnostic tool is also addressed.
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Nature 330: 379-381 (26 Nov. 1987) Hediger et al Expression cloning and cDNA sequencing of the Na.sup.+ /glucose co-transporter.
Biochemistry 29:3349-3354, 1990, Jul., Biessen et al. Parts of Purification of the 5-Hydroxytryptamine Reuptake System from Human Blood Platelets . . . .
Pletscher, International Journal of Cardiology, 14 (1987) 177-188, The 5-hydroxytryptamine system of blood platlets: physiology and pathophysiology.
Nelson et al, FEBS 08757, vol. 269, No. 1, 181-184 Cloning of the human brain GABA transporter.
Guastella, et al, Science, Sep. 14, 1990, 1303-1306, vol. 249 Cloning and Expression of a Rat brain GABA Transporter.
Pacholszyk et al, Nature, vol. 350, Mar. 28, 1991, 350-354, Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter.
Brownstein Michael J.
Hoffman Beth J.
Mezey Eva
Draper Garnette D.
The United States of America as represented by the Department of
Ulm John D.
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