CDNA clone HNFDY20 that encodes a human 7-transmembrane receptor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 4353201, 530350, 536 235, C07K 14705, C12N 1512

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active

059424168

ABSTRACT:
HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

REFERENCES:
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GenBank Accession No. U62631.
Sawzdargo et al.; "A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occuring in Close Proximity to CD22 Gene on Chromosome 19q13.1", Bioch Biophys Reg. Comm., vol. 239, pp. 543-547 (1997).
Oliveira et al.; "A common motif in G-protein coupled seven transmembrane helix receptors", Journal of Computer-Aided Molecular Design, vol. 7, pp. 649-658 (1993).
Coughlin, et al., "Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation", Cell, 64, pgs. 1057-1068, Mar. 22, 1991.
Coughlin, et al., "Specificity of the Thrombin Receptor for Agonist Peptide is Defined by Its Extracellular Surface", Letters to Nature, 368, pgs. 648-651, Apr. 14, 1994.
Lustig, et al., "Expression Cloning of an ATP Receptor from Mouse Neuroblastoma Cells", Proc. Natl. Acad. Sci. USA, 90, pgs. 5113-5117, Jun. 1993.
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