Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-10-23
1999-09-21
Teng, Sally P.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 243, 435 691, 4352523, 43525411, 4353201, 435325, C12N 1512
Patent
active
059553081
ABSTRACT:
HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers;astma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourettt's syndrome, among others, and diagnostic assays for such conditions.
REFERENCES:
Nomura, H. et al., "Molecular cloning of cDNs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors", Int. Immunol., vol. 5 (10), pp. 1239-1249, (1993).
Parr, C.E. et al., "Cloning and expression of a human P.sub.2U nucleotide receptor, a target for cyctic fibrosis pharmacotherapy", Proc. Natl. Acad. Sci. U.S.A., vol. 91, pp. 3275-3279, (1994).
Bergsma Derk J
Halsey Wendy S
Mooney Jeffrey L
Sathe Ganesh M
Hecht Elizabeth J.
King William T.
SmithKline Beecham Corporation
Teng Sally P.
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