Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-01-10
2000-01-04
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435440, 435455, 530350, 536 231, 536 235, C12P 2106, C07H 2104, C07K 100, C12N 1500
Patent
active
060108770
ABSTRACT:
HE8CS41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE8CS41 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
Mori et al. Primary Structure and Functional Expresssion from complementary DNA of a Brain Calcium Channel. Nature, vol. 350, pp. 398-402, Apr. 4, 1991.
Nejidat et al. Transfer of the Movement Protein Gene between Two Tobamoviruses: Influence on Local Lesion Development. Virology, vol. 180, pp. 318-326, 1991.
Kaplan, M.H. et al., Identification of a G Protein Coupled Receptor Induced in Activated T Cells, J. Immun., 1993, 151:628-636.
Toguchida, J. et al., "Complete Genomic Sequence of the Human Retinoblastoma Susceptibility Gene", Genomics, 1993, 17:535-543.
Murphy, T.J., et al., "A Cloned Angiotensin Receptor Isoform from the Turkey Adrenal Gland is Pharmacologically Distinct from Mamallian Angiotensin Receptors", Mol. Pharmacol., 1993, 44:1-7.
Auffray, C., et al., "Image: integration au niveau moleculaire de l'analyse du genome humain et de son expression", C.R. Acad. Sci. Paris, 1995, 318(2), 263-272 (see also Auffray, C. et al. GenBank Submission, Accession No. F07588, H. sapiens partial cDNA sequence; clone c-2bd07).
Hillier, L., et al., GenBank Submission, Accession No. H20663, ym47h08.r1Homo sapiens cDNA clone 51646 5' similar to SP:GCRT.sub.-- CHICK P32250 Probable G Protein-Coupled Receptor 6H1 From;.
Bergsma Derk Jon
Horn Stephanie Van
Mao Joyce Yue
Sathe Ganesh M
Campell Bruce R.
Clark Deborah J. R.
Han William T.
King William T.
SmithKline Beecham Corporation
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