cDNA clone for South African Arbovirus No. 86

Details cDNA clone for South African Arbovirus No. 86 cDNA clone for South African Arbovirus No. 86

1995-05-23

1997-06-17

Guzo, David

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4353201, 536 231, 536 2372, C12N 704, C12N 1586

Patent

active

056396503

ABSTRACT:
The present invention provides a recombinant DNA comprising a cDNA coding for an infectious South African Arbovirus No. 86 (S.A.AR86) virus RNA transcript and a heterologous promoter positioned upstream from the cDNA and operatively associated therewith. The present invention also provides an infectious RNA transcript encoded by the cDNA, and infectious attenuated viral particles containing the RNA transcript encoded by the cDNA.

REFERENCES:
patent: 4650764 (1987-03-01), Temin et al.
patent: 5185440 (1993-02-01), Davis et al.
patent: 5217879 (1993-06-01), Huang et al.
Strauss et al., "The Alphaviruses: Gene Expression, Replication, and Evolution", Microbiol. Rev., vol. 58, No. 3, pp. 491-562.
Russell, et al., Sindbis Virus Mutations Which Coordinately Affect Glycoprotein Processing, Penetration, And Virulence In Mice, Journal of Virology, vol. 63, No. 4, Apr. 1989, pp. 1619-1629.

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