Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1994-09-28
1995-11-21
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435 691, 4352523, 43525233, 4353701, 536 232, 935 9, 935 14, 935 27, 935 68, 935 70, 935 73, C12N 902, C12N 1553, C12N 1570, C12N 1579
Patent
active
054686300
ABSTRACT:
A human tissue inducible nitric oxide synthase cDNA clone is disclosed. A process for preparing this cDNA clone coding for human tissue inducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein are provided.
REFERENCES:
patent: 4652639 (1987-03-01), Stabinsky
patent: 4882282 (1989-11-01), Anderson et al.
patent: 5017691 (1991-05-01), Lee et al.
patent: 5132407 (1992-07-01), Stuehr et al.
patent: 5171674 (1992-12-01), Stevens et al.
patent: 5189957 (1993-02-01), Short et al.
patent: 5216131 (1993-06-01), Lasky et al.
patent: 5223425 (1993-06-01), Flier et al.
patent: 5236844 (1993-08-01), Bassett et al.
patent: 5239060 (1993-08-01), Kunkel et al.
patent: 5268295 (1993-12-01), Serrero
patent: 5268465 (1993-12-01), Bredt et al.
patent: 5278299 (1994-01-01), Wong et al.
Lowsenstein, et al.; 1992; Cloned and expressed macrophage nitric oxide shase contrasts with the brain enzyme; Proc. Natl. Acad. Sci. USA; vol. 89, pp. 6711-6715.
Bredt, et al.; 1991; Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase; Nature; vol. 351; pp. 714-718.
Xie, et al.; 1992; Cloning and Characterization of Inducible Nitric oxide Synthase from Mouse Macrophages; Science; vol. 256; pp. 225-228.
Lyons, et al.; 1992; Molecular Cloning and Functional Expression of an Inducible Nitric Oxide Synthase from a Murine Macrophage Cell Line; The Journal of Biological Chemistry; vol. 267; pp. 6370-6374.
Marsden, et al.; 1992; Molecular cloning and characterization of human endothelial nitric oxide synthase; FEBS Letters; vol. 307, pp. 287-293.
Palmer, et al.; 1987; Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor; Nature; vol. 327, pp. 524-526.
Ignarro, et al.; 1987; Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide; Proc. Natl. Acad. Sci, USA; vol. 84, pp. 9265-9269.
Bredt and Snyder; 1989; Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum; Proc. Natl. Acad. Sci. USA; vol. 86, pp. 9030-9033.
Burnett, et al.; 1992; Nitric Oxide: A Physiologic Mediator of Penile Erection; Science; vol. 257; pp. 401-403.
Granger, et al.; 1988; Specific Amino Acid (L-Arginine) Requirement for the Microbiostatic Activity of Murine Macrophages; J. Clin. Invest.; vol. 81, pp. 1129-1136.
Hibbs, Jr., et al.; 1987; Macrophage Cytoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite; Science; vol. 235, pp. 473-476.
Busse and Mulsch; 1990; Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin; FEBS Letters; vol. 265, pp. 133-136.
Kilbourn, et al.; 1990; N.sup.6 -Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide; Proc. Natl. Acad. Sci. USA; vol. 87, pp. 3629-3632.
Mulligan, et al.; 1992; Lung Injury after deposition of IgA immune complexes; J. Immunology vol. 148, pp. 3086-3092.
Corbett, et al.; 1991; Interleukin-1.beta.-induced Formation of EPR-detectable Iron-Nitrosyl Complexes in Islets of Langerhans; The Journal of Biological Chemistry; vol. 266, pp. 21351-21354.
Nussler, et al.; 1992; FASEB Meeting; Anaheim, Calif. Stimulation of Nitric Oxide in Human Hepatocytes By Cytokines, Abst. 5200.
Nussler, et al.; 1992; Stimulation of the Nitric Oxide Synthase pathway in Human Hepatocytes by Cytokines and Endotoxin; J. Exp. med. vol. 176, pp. 261-264.
J. C. Drapier; 1991; Res. Immoc., 39th Forum In Immunoc.; See specifically pp. 557, 562 and 589-590.
Summers and Smith; 1988; A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures; Texas Agricultural Experiment Station Bulletin No. 1555, pp. 3-56.
Evans, et al.; 1992; Purification of a distinctive form of endotoxin-induced nitric oxide synthase from rat liver; Proc. Natl. Acad. Sci. USA; vol. 89, pp. 5361-5365.
Curran, et al.; 1991; Nitric oxide and nitric oxide.varies.generating compounds inhibit hepatocyte protein synthesis; FASEB; vol. 5, pp. 2085-2092.
Billiar, et al.; 1992; Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes; American Physiological Society; pp. C1077-C1082.
Billiar, et al.; 1990; Inducible Cytosolic Enzyme Activity for the Production of Nitrogen oxides from L-arginine in Hepatoycytes; Bioch. Biophys. Res. Comm; vol. 168, pp. 1034-1040.
Billiar, et al.; 1989; An L-arginine-dependent Mechanism Mediates Kupffer Cell Inhibition of Hepatocyte Protein Synthesis in Vitro; J. Exp. Med.; vol. 169; pp. 1467-1472.
Stadler, et al.; 1991; Effect of exogenous and endogenous nitric oxide on mitochondrial American Physiological Society; pp. C910-C916.
Ochoa, et al.; 1991; Nitrogen Oxide Levels in Patients after Trauma and During Sepsis, Ann. Surg. 214: 621-626.
Billiar, et al.; 1990; Modulation of Nitrogen Oxide Synthesis In Vivo J. Leuk. Biol. 48: pp. 565-569.
Ochoa, et al.; 1992; Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation with Toxic Hemodynamic Changes; Journal of the National Cancer Institute; pp. 864-867.
Curran, et al.; 1990; Multiple Cytokines Are Required to Induce Hepatocyte Nitric Oxide Production and Inhibit Total Protein Synthesis; Ann. Surg. 212: pp. 462-471.
Curran, et al.; 1989; Hepatocytes Produce Nitrogen Oxides from L-Arginine in Response to Inflammatory Products of Kupffer Cells; J. Exp. Med.; vol. 170, pp. 1769-1774.
Finkel, et al.; 1912, Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide Science 257: 387`389.
Billiar, T. R., et al., 1991, Research in Immunology, 142:584-586.
Hibbs, J. B., Jr., et al., 1992, Journal & Clinical Investigation 89:867-877.
Denis, M., 1991, Journal of Leukocyte Biology, 49:380-387.
Hunt, M. C. A., et al., 1992, Journal of Heptology, 14:146-150.
Munnoz -Fernandez, M. A., et al., 1992, Immunology Letters, 33:35-40.
Cameron, M. L., et al., 1990, American Review of Respiratory Disease, 142:1313-1319.
Sherman, M. P., et al., 1991, Journal of Photozoology, 38(6):2345-2365.
James, S. L., et al., 1990, Journal of Immunology, 145:2686-2690.
Padgett, E. L., et al., 1992, Biochemical and Biophysical Research Communications, 186(2):775-781.
Denis, M., 1994, Journal of Leukocyte Biology 55:682-684.
Bredt, D. S., et al., 1990, Proceedings of the National Academy of Sciences, U.S.A. 87:682-685.
Billiar, T. R., et al., 1991, FASEB Journal 5(5): A1344, Abstract No. 5642.
Knowles, R. G., et al., 1990, Biochemical and Biophysical Research Communications, 172(3): 1042-1048.
Stadler, J., et al., 1991, Archives of Surgery, 126(2):186-191.
Nathan, C., 1991, Research in Immunology, 142(7):600-602.
Wright, C. E., 1992, Cardiovascular Research, 26(1): 48-57.
DiSilvio, M., et al., 1992 Gastroenterology 102: A801, abstract.
Klatt, P., et al., 1992, Journal of Biological Chemistry, 267(16):11374-11378.
Oguchi, S., et al., 1992, FEBS Letters, 308(1):22-25.
Harbrecht, B. G., et al., 1992, Journal of Leukocyte Biology, 52(4):390-394.
Harbrecht, B. G., et al., 1992, Critical Care Medicine 20:1568-1574.
Nussler, A. K., et al., 1992, Journal of Leukocyte Biology, Supplement 3:137, Abstract No. 146.
Kontkamp, E., et al., 1986, DNA, 5(6):511-517
Sherman, P. A., et al., 1993, Biochemistry, 32:11600-11605.
Chartrain, N. A., et al., 1994, Proceedings of the National Academy of Sciences, U.S.A., 269(9):6765-6772.
Hokari, A., et al., 1994, Journal of Biochemistry 116:575-581.
Charles, I. G., et al., 1993, Proceedings of the National Academy of Sciences, U.S.A., 90: 11419-11423.
Lamas, S., et al., 1992, Proceedings of the National Academy of Sciences, U.S.A., 89(14):6348-6352.
Lelchuk, R., et al., 1992, The Journal of Pharmacology and Experimental Therapeutics, 262(3):1220-1224.
Janssens, S. P., et al., 1992, The Journal of Biological Chemistry, 267(21):14519-14522.
Siebert, P. D., et al., 1992, Nature, 359(6395):557-558.
Knowles, R. G., et al., 1990, The Biochemical Journal, 270:833-836.
Salter, M., et al., 1991, FEBS Letters, 291(1):145-149.
Springall, D. R., et al., FEBS Letters, 29(1):145-149.
Springall, D. R., et
Billiar Timothy R.
Geller David A.
Nussler Andreas K.
Simmons Richard L.
Moore William W.
University of Pittsburg of the Commonwealth System of Higher Edu
Wax Robert A.
LandOfFree
cDNA clone for human inducible nitric oxide synthase and process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with cDNA clone for human inducible nitric oxide synthase and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and cDNA clone for human inducible nitric oxide synthase and process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1136262