CDNA clone encoding brain amyloid of alzheimer's disease

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 28, 536 29, 435 6, 530324, C07H 19073

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049122061

ABSTRACT:
Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.

REFERENCES:
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Stearman et al., Nucleic Acids Research, vol. 14 (2), pp. 797-809, 1986.
Wurtman et al., Alzheimer's Disease: Advances in Basic Research and Therapies, Zurich, Switzerland, Jan. 16-18, 1987.
UCLA Symposium "Molecular Biology of Human Brain", Keystone, Colo., Apr. 20-25, 1987.
Goldgaber et al., Science, 235:887-880, 1987, "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease".
Delabar et al., Science 235:1390-1392, 1987, "Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome".

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