Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1987-02-26
1990-03-27
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 28, 536 29, 435 6, 530324, C07H 19073
Patent
active
049122061
ABSTRACT:
Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.
REFERENCES:
patent: 4666829 (1987-05-01), Glenner et al.
King et al., A Dictionary of Genetics, Oxford Univ. Press, New York, 1985, p. 76.
Glover, Gene Cloning, Chapman and Hall, New York, 1984, Supp. 102-104
Old et al., Principles of Gene Manipulation, Univ. of California Press, Berkeley, Calif., 1981, Supp. 104, 105, 119 & 120.
Kunisada et al., Nucleic Acids Research, vol. 14 (14), pp. 5729-5740, 1986.
Stearman et al., Nucleic Acids Research, vol. 14 (2), pp. 797-809, 1986.
Wurtman et al., Alzheimer's Disease: Advances in Basic Research and Therapies, Zurich, Switzerland, Jan. 16-18, 1987.
UCLA Symposium "Molecular Biology of Human Brain", Keystone, Colo., Apr. 20-25, 1987.
Goldgaber et al., Science, 235:887-880, 1987, "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease".
Delabar et al., Science 235:1390-1392, 1987, "Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome".
Gajdusek D. Carleton
Goldgaber Dmitry Y.
Lerman Michael
Crane L. Eric
Griffin Ronald W.
Jain Mishrilal L.
The United States of America as represented by the Department of
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