Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-06-20
1993-02-09
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4352351, 435236, 4353201, 424 89, 424 93A, 935 10, 935 65, C12N 1540, C12N 701, C12N 704, A61K 39193
Patent
active
051854406
ABSTRACT:
A DNA comprises a cDNA clone coding for an infectious Venezuelan Equine Encephalitis Virus RNA transcript and a heterologous promoter sequence positioned upstream from the cDNA clone and operatively associated therewith. A method of making a live attenuated Togavirus useful as a vaccine, and cDNA clones which code for attenuated Togaviruses, is also disclosed.
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Davis, N. et al., "A Single Nucleotide Change in the E2 Glycoprotein Gene of Sindbis Virus Affects Penetration Rate in Cell Culture and Virulence in Neonatal Mice," Proc. Natl. Acad. Sci. USA 83, 6221 (1986).
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Davis Nancy L.
Johnston Robert E.
Smith Jonathan F.
Willis Loretta V.
Mosher Mary E.
North Carolina State University
Schwartz Richard A.
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