Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1989-02-02
1990-10-30
Mays, Thomas D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 43524025, 4352523, 435320, 530399, 536 27, 935 13, 935 14, 935 28, 935 29, 935 70, 935 71, 935 73, C12N 922, C12N 1500, C07K 300, C07H 1512
Patent
active
049668498
ABSTRACT:
DNA sequences encoding a protein having angiogenic activity and mutated DNA sequences encoding a protein having decreased angiogenic activity are disclosed. Expression vectors containing these wild-type or mutated sequences are introduced into host cells and direct the production of wild-type or mutant angiogenic proteins. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes. Mutant proteins produced according to the invention are useful therapeutic compositions as angiogensis inhibitors, which may retard tumor growth by inhibiting the development of a hemovascular network.
REFERENCES:
patent: 4229531 (1980-10-01), Tolbert et al.
patent: 4503038 (1985-03-01), Banda et al.
patent: 4721672 (1988-01-01), Vallee et al.
patent: 4727137 (1988-02-01), Vallee et al.
Holmes et al., Cell 32:1029-1032 (1983).
Brosius et al., J. Mol. Biol. 148:107-127 (1981).
Maniatis et al. In Molecular Cloning, a Laboratory Manual. Cold Spring Harbor, (1982), pp. 405-410.
Battersby, T., Plating of Mandibular Fractures, British J. Oral Surg., 194-201 (no date).
J. Natl. Cancer Inst. 41:111-124 (1968 Greenblatt and Shubik).
Auerbach, in Lymphokines, Pick and Landy, etd. 69-88, Academic Press, New York, 1981.
Invest. Opthalm. Vis. Sci. 22:191-199 (1982, Berman et al.).
J. Natl. Cancer Inst. 69:1183-1188 (1982, Raju et al.).
Proc. Natl. Acad. Sci. USA 79: 7773-7777 (1982, Banda et al.).
Proc. Natl. Acad. Sci. USA 78: 3068-3072 (1981, D'Amore et al.).
J. Exp. Med. 133: 275-288 (1971, Folkman et al.).
Biochemistry 12: 3159-3165 (1973, Tuan et al.).
Int. J. Cancer 23: 82-88 (1979, Phillips and Kumar).
Ewers, R., Experimental and Clinical Results of New Advances in the Treatment of Facial Trauma, Plastic and Reconstructive Surg., 25-31 (Jan. 1985).
Br. J. Cancer 40: 493-496 (1979, Weiss et al.).
J. Biol. Chem. 256: 9605-9611 (1981, Fenselau et al.).
Int. J. Cancer 32: 461-464 (1983, Kumar et al.).
Experientia 41: 1-15 (1985, Vallee et al.).
Jones, R., Military Orthopedic Surgery, Surgery, Its Principles and Practice, pp. 624-675 (1909 Saunders).
Biochemistry 24: 5480-5486 (1985, Fett et al.).
Biochemistry 25: 3527-3532 (1986, Shapiro et al.).
Gene 56: 61-70 (1987, Denefel et al.).
Biochemistry 24: 5486-5494 (1985, Strydom et al.).
FASEB Abstract #4309, 61st Annual Meeting, Chicago, 1977 (Rettura et al.).
Cancer Res. 36: 110-114 (1976, Klagsbrun et al.).
Science 195: 880-881 (1977, Brem et al.).
Br. J. Cancer 35: 347-356 (1977, Knighton et al.).
Nature 263: 797-800 (1976, Langer and Folkman).
Proc. Natl. Acad. Sci. USA 76: 4350 (1979, Towbin et al.).
Proc. Natl. Acad. Sci. USA 82: 488-494 (1985, Kunkel).
Proc. Natl. Acad. Sci. 74: 5463-5467 (1977, Sanger et al.).
Roed-Petersen, B., Absorbable Synthetic Suture Material for Internal Fixation of Fractures of the Mandible, 3 Int. J. Oral Surg., 133-36 (1974).
The EMBO Journal 4: 519-526 (1985, McCarthy et al.).
Gene 41: 201-206 (1986, McCarthy et al.).
Biochemistry 26: 5141-5146 (1987, Shapiro et al.).
Methods in Enzymology 101: 155-164 (1983, Nicholas and Yanofsky).
Gene 2: 95-113 (1977, Bolivar et al.).
Methods in Enzymology 101: 20-78 (1983, Messing).
Gene 19: 259-268 (1982, Viera and Messing).
Nature 275: 104-108 (1978, Beggs).
Gene 8: 121-133 (1979, Broach et al.).
J. Biol. Chem. 255: 12073-12080 (1980, Hiteman et al.).
J. Mol. Appl. Genet. 1: 419-434 (1982, Alber and Kawasaki).
Cell 30: 933-943 (1982, Kurtan and Herskowitz).
Science 222: 809-814 (1983, Palmiter et al.).
Cell 15: 687-701 (1978, Maniatis et al.).
J. Mol. Biol. 113: 237-251 (1977, Rigby et al.).
Science 196: 180-182 (1977, Benton and Davis).
Nucleic Acids Res. 9: 309-321 (1981, Messing et al.).
Gene 26: 101-106 (1983, Norrander et al.).
Proc. Natl. Acad. Sci. USA 79: 4298-4302 (1982, Poncz et al.).
Methods in Enzymology 100: 60-97 (1983, Guo and Wu).
Science 216: 1065-1070 (1982, Schmid and Jelineck).
Nature 263: 211-214 (1976, Proudfoot and Brownlee).
Thrombosis and Hemostasis 54: 282 (1985, Kurachi and Palmiter).
Anal. Biochem. 131: 385-393 (1983, Durnam and Palmiter).
Cell 19: 753-764 (1980, Nasmyth and Tatchell).
Proc. Natl. Acad. Sci. USA 84: 4767-4771 (1987, Tabor and Richardson).
J. Biol. Chem. 254: 12484-124876 (1979, Blackburn).
Proc. Natl. Acad. Sci. 84: 2238-2241 (1987, Shapiro and Vallee).
Fogh and Trempe, in Human Tumor Cells in Vitro, Fogh ed., 115-160, Plenum, New York, 1975.
Biochemistry 27: 219-226 (1987, Harper et al.).
J. Chromatography 336: 93-104 (1984, Bidlingmeyer et al.)
Methods in Enzymology 154: 367-382 (1987, Kunkel et al.)
Kurachi Kotoku
Vallee Bert L.
Mays Thomas D.
President and Fellows of Harvard College
LandOfFree
CDNA and genes for human angiogenin (angiogenesis factor) and me does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with CDNA and genes for human angiogenin (angiogenesis factor) and me, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CDNA and genes for human angiogenin (angiogenesis factor) and me will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-274958