Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1996-04-01
1998-05-26
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, C07K 1400
Patent
active
057566712
ABSTRACT:
The present invention relates to the discovery in mammalian cells, particularly human cells, of a novel CDK-binding protein, referred to herein as "cdc37". As described herein, this protein functions to facilitate activation and accordingly functions in the modulation of cell-cycle progression, and therefore ultimately of cell growth and differentiation. Moreover, binding data indicated that cdc37 may function coordinately with other cell-cycle regulatory proteins, such as of cyclin-dependent kinases (CDKs), src, p53 and erk kinases.
REFERENCES:
Ngo et al. In The Protein Foling Problem and Tertiary Structure Production (1994), Merz et al (ed.) Birkhauser, Boston, MA pp. 433, 452-455.
Draetta Giulio
Gyuris Jeno
Lamphere Lou
Arnold, Esq. Beth E.
Mitotix, Inc.
Sorensen Kenneth A.
Vincent, Esq. Matthew P.
Walsh Stephen
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