Cdc2 protein kinase from pneumocystis carinii

Details Cdc2 protein kinase from pneumocystis carinii Cdc2 protein kinase from pneumocystis carinii

1998-06-08

2000-01-18

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

4353201, 435325, 4352523, 435 691, 536 232, C12N 900, C12P 2106, C07H 1700

Patent

active

060157003

ABSTRACT:
A nucleic acid and corresponding polypeptide that aids in the regulation of the cell cycle in Pneumocystis carinii is described. Antibodies generated against a unique carboxyl-terminus region of the polypeptide have specific binding affinity for P. carinii Cdc2 polypeptide and are benificial in diagnosing and monitoring P. carinii infection in patients. Expression of P. carinii Cdc2 polypeptide in cdc2-mutant yeast and other cdc2-mutant organisms provides a for model for studying the life cycle of P. carinii and for identifying novel therapeutics.

REFERENCES:
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Thomas et al., "Identification of a Cell Division Cycle (cdc2) Homologue in Pneumocystis carinii," J. Euk. Micro, vol. 43, No. 5, Sep.-Oct. 1996.
Thomas et al., "The Pneumocystic Carinii cdc2 Cell Division Cycle Homologue Exhibits Characteristics Protein Kinase Activity," Chest, 110:66S (1996).
Thomas et al., "Partial Cloning of the Pneumocystis carinii Cell Division cycle (cdc2) Homologue Using Polymerase Chain Reaction," J. Invest. Med., 44:397A (1996).
Thomas et al., "Evidence for a Pneumocystis Carinii Cell Division Cycle (cdc2) Homologue," Am. J. Resp. Care Med., 153:A433 (1996).
J. Pines, "The cell cycle kinases," Seminars in Cancer Biology, 5:305-313 (1994).
Fleig et al., "Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation," Seminars in Cell Biology, 2:195-204 (1991).
Sambrook et al., Molecular Cloning, second edition, Cold Spring Harbor Laboratory, Plainview, NY (Sections 7.39-7.52) (1989).
Dayhoff, et al., "A Model of Evolutionary Change in Proteins," Atlas of Protein Sequencing and Structure, vol. 5, Suppl. 3, pp. 345-352 (1978).

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