Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1993-09-17
1996-10-15
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 424577, 4241841, 435 72, 435 724, C07K 100, A61K 3526, G01N 3353, G01N 33567
Patent
active
055655491
ABSTRACT:
A protein secreted by peripheral blood mononuclear cells and specifically from CD8.sup.+ lyphocytes is purified and characterized here and designated CD8.sup.+ cell antiviral factor (CAF). The CAF is lipid free, has a molecular weight of less than 30,000 and has been found to inhibit the replication of retroviruses and in particular to inhibit the replication of HIV-1, HIV-2, and SIV. CAF can be used to inhibit viral RNA transcription which inhibits viral replication. Accordingly, CAF can be used to treat patients infected with retroviruses. The CAF can also generate antibodies which can be used to create assay reagents for detecting CAF in a body fluid and on the surface of CD8.sup.+ cells to determine the condition of an HIV infected individual.
REFERENCES:
patent: 4818683 (1989-04-01), Morel et al.
Brinchmann et al., "CD8+ T Cells Inhibit HIV Replication in Naturally Infected CD4+ T Cells" J. Immunol. (1990) 144:2961-2966.
Mackewicz et al., "CD+8 Cell Anti-HIV Activity Correlates with the Clinical State of the Infected Individual" J. Clin. Invest. (1991) 87:1462-1466.
Walker et al., "CD+8 Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication" Science (1986) 234: 1563-1566.
Walker et al., "A Diffusable Lymphokine Produced by CD+8 T Lymphocytes Suppresses HIV Replication" Immunology (1989) 66:628-630.
Castro et al., "Suppression of Human Immunodeficiency Virus Replication by CD8+ Cells from Infected and Uninfected Chimpanzees," Cellular Immunology (1991) 132:246-255.
Hames, et al (Ed.), 1981, "Gel Electrophoresis of Proteins: A Prachial Approach". pp. 63-64, 71-73, 219-225.
Haynes, et al, 1993, "Scienhfic and Social Issues of human . . . . " Science 260:1279-1286.
Butini, et al, 1994, "Comparative analysis of HIV-Specific . . . . " J. Cell. Biochem. Suppl. 18B, Abstract. J306.
Scopes, 1982, "Protein Purification: Principles and Prachie", pp. 14-16, 60-65.
Deutscher, 1990 "Guide to Protein Purification". Methods In Enzymology vol. 182. 626-646.
Levy Jay A.
Mackewicz Carl E.
Bozicevic Karl
Smith Lynette F.
The Regents of the University of California
LandOfFree
CD8.sup.+ cell antiviral factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with CD8.sup.+ cell antiviral factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CD8.sup.+ cell antiviral factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1247269