Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-09-16
1996-12-03
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 72, 435 724, 4241841, 424577, 530350, C12N 1500, G01N 3353, C07K 100, A61K 3900
Patent
active
055807690
ABSTRACT:
A protein secreted by peripheral blood mononuclear specifically from CD8.sup.+ lymphocytes is purified and characterized here and designated CD8.sup.+ cell antiviral factor (CAF). The CAF is lipid free and has been found to inhibit the replication of retroviruses and in particular to inhibit the replication of HIV-1, HIV-2, and SIV. CAF can be used to inhibit viral RNA transcription which inhibits viral replication. Accordingly, CAF can be used to treat patients infected with retroviruses. The CAF can also generate antibodies which can be used to create assay devices for detecting CAF in a body fluid and on the surface of CD8.sup.+ cells to determine the condition of an HIV infected individual.
REFERENCES:
patent: 4818683 (1989-04-01), Morel et al.
Brichmann et al., "CD8.sup.+ T Cells Inhibit HIV Replication in Naturally Infected CD 4 +T Cells: Evidence for a Soluble Inhibitor," J. Immunol. (1990) 144:2961-2966.
Mackewicz et al., "CD8.sup.+ Cell Anti-HIV Activity Correlates with the Clinical State of the Infected Individual," J. Clin. Invest. (1991) 87:1462-1466.
Walker et al., "CD8.sup.+ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication," Science (1986) 234:1563-1566.
Walker et al., "A Diffusable Lymphokine Produced by CD8.sup.+ T Lymphocytes Suppresses HIV Replication," Immunology (1989) 66:628-630.
Castro et al., "Suppression of Human Immunodeficiency Virus Replication by CD8.sup.+ Cells from Infected and Uninfected Chimpanzees," Cellular Immunology (1991) 132:246-255.
Laurence, et al, 1990, "A soluble inhibitor of . . . " Cellular Immunology 128:337-352.
Castro, et al, 1991, "Suppression of human . . . " Cellular Immunology 135:246-255.
Levy Jay A.
Mackewicz Carl E.
Bozicevic Karl
Smith Lynette F.
The Regents of the University of California
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