CD8 epitope from HIV-1 protein Vpu

Details CD8 epitope from HIV-1 protein Vpu CD8 epitope from HIV-1 protein Vpu

2006-04-04

2006-04-04

Stucker, Jeffrey (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S184100, C424S185100, C424S186100, C424S187100, C424S188100, C514S002600, C530S300000, C530S328000

Reexamination Certificate

active

07022325

ABSTRACT:
The invention relates to the identification and the selection of CTL epitopes able to induce a protection against an HIV infection. More particularly, the invention is concerned with peptides and nucleic acid sequence coding for these peptides derived from HIV-1 proteins such as GAG, POL, ENV, VIF, TAT, VPU, REV and their applications. Preferably the immunogenic peptides are selected from the group consisting of SEQ ID NOs:1 to 18 and functional derivatives thereof. The invention also relates to antibodies directed against said peptides.

REFERENCES:
patent: WO 99/45954 (1999-09-01), None
patent: WO 99/586658 (1999-11-01), None
patent: WO 01/24810 (2001-04-01), None
patent: WO 02/20035 (2002-03-01), None
Jin et al. “Identification of subdominant cytotoxic T lymphocyte epitopes encoded by autologous HIV type 1 sequences, using dendritic cell stimulation and computer-driven algorithm”, Jan. 1, 2000, AIDS Research Human Retroviruses vol. 16, No. 1, pp. 67-76.
Kusk et al. Mapping of a New Immunodominant Human Linear B-cell Epitope on the Vpu protein of the HIV-1 1993. Journal of Acquired Immune Deficiency Syndromes vol. 6, pp. 334-338.
Jin, X. et al., “Identification of Subdominant Cytotoxic T Lymphocyte Epitopes Encoded by Autologous HIV Type 1 Sequences, Using Dendritic Cell Stimulation and Computer-Driven Algorithm”, Aids Research and Human Retroviruses, vol. 16, pp. 67-76, (Nov. 1, 2000).
Los Alamos National Laboratory, HIV Database, Immunology Database, Online!—Dec. 2000, Retrieved from the Internet: url:http://hiv-web.lanl.gov/content/hiv-db/immunology/PDF/2000/2/alignments/p2p7p1p6.pdf, Retrieved on Jul. 14, 2003!.
Aids Vaccine 2001, Posters Conference 2001, Online!—(Sep. 8, 2001), XP-002247713, Retrieved form the Internet: URL:http://www.aidsvaccine2001.org/Posters/305.pdf, Retrieved on Jul. 15, 2003!.

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