Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-09-14
1998-12-08
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 235, 536 2431, 536 2433, C12Q 168, C07H 2104
Patent
active
058467157
ABSTRACT:
CD46 (membrane cofactor protein) is a family of human cell surface glycoprotein with cofactor activity for factor I mediated cleavage of complement components C3b and C4b. Disclosed are novel nucleic acid sequences arising from splice variants or derivatives thereof of the structural gene encoding the family of proteins. From these sequences recombinant derived proteins and antibodies thereto can be produced. The proteins can resemble native CD46 isoforms or comprise new permutations of exons within the structural gene. The nucleic acids, proteins and antibodies have utility as probes, diagnostic reagents and therapeutic agents.
REFERENCES:
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McKenzie Ian Farquar Campbell
Purcell Damian Francis John
Russell Sarah May
Horlick Kenneth R.
The Austin Research Institute
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