Cd45 inhibitors

Details Cd45 inhibitors Cd45 inhibitors

2005-09-06

2005-09-06

Badio, Barbara P. (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C552S292000

Reexamination Certificate

active

06939896

ABSTRACT:
Substituted naphthalenediones in accord with structural diagram (I): compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, wherein: Q1at each occurrence is independently selected from hydrogen, hydroxy, halogen, C(O)O(C1-C3) alkyl and C(O)phenyl, and Q2is selected from hydrogen, halogen, O—(C1-C3)alkyl, O—(C1-C3)alkenyl, phenyl, indolyl and naphthyl, where phenyl may be mono- or di-substituted with NO2or halogen, and indolyl may be substituted with (C1-C3)alkyl or phenyl

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A.N. Grinev et al.: “Synthesis of bis(diethylaminoethyl) -1,2-dimethyl-8-oxoindeno [2,1-b] pyrroloe-3,5-dicarboxylate.” Chemistry of Heteroxyxlic Compounds (English Translation), vol. 19, 1983, pp. 876-879, XP001026781 p. 877, compound No. 1.
R.A. Urbanek et al. : “Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45” Journal of Medicinal Chemistry, vol. 44, 2001, pp. 1777-1793, XP001014517 tables 1-3.

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