CD44-like protein and nucleic acids

Details CD44-like protein and nucleic acids CD44-like protein and nucleic acids

1997-07-15

1999-08-24

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 435 711, 4352523, 4353201, 435325, 530350, 5303871, 536 235, 536 243, 536 2431, C12N 1500, C07H 2104, C07K 100

Patent

active

059424176

ABSTRACT:
The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.

REFERENCES:
patent: 5504194 (1996-04-01), St. John et al.
Genbank Report, Accession No. AA046671, Hillier et al. (Sep. 1996).
Genbank Report, Accession No. AA081351, Hillier et al. (Oct. 1996).
Genbank Report, Accession No. AA046747, Hillier et al. (Sep. 1996).
Genbank Report, Accession No. N69434, Hillier et al. (Mar. 1996).
Genbank Report, Accession No. W69477, Hillier et al. (Jun. 1996).
Genbank Report, Accession No. H69328, Hillier et al. (Oct. 1995).
Genbank Report, Accession No. W03259, Hillier et al. (Apr. 1996).
Genbank Report, Accession No. W03670, Hillier et al. (Apr. 1996).
Genbank Report, Accession No. H59965, Hillier et al. (Oct. 1995).
Genbank Report, Accession No. N80143, Hillier et al. (Apr. 1996).
Genbank Report, Accession No. W87511, Hillier et al. (Feb. 1997).
Genbank Report, Accession No. H93850, Hillier et al. (Dec. 1995).
Genbank Report, Accession No. AA463325, Hillier et al. (Jun. 1997).
Genbank Report, Accession No. AA340162, Adams et al. (Apr. 1997).
Genbank Report, Accession No D79275, Fujiwara et al. (Feb. 1996).
Genbank Report, Accession No. H72432, Hillier et al. (Oct. 1995).
Genbank Report, Accession No. R71437, Hillier et al. (Jun. 1995).
Genbank Report, Accession No. R93568, Hillier et al. (Aug. 1995).
Genbank Report, Accession No. H02824, Hillier et al. (Jun. 1995).
Genbank Report, Accession No. AA297240, Adams et al. (Apr. 1997).
Genbank Report, Accession No. H80143, Hillier et al. (Nov. 1995).
Genbank Report, Accession No. D63040, Fujiwara et al. (Aug. 1995).
Genbank Report, Accession No. H02823, Hillier et al. (Jun. 1995).
Genbank Report, Accession No. T96905, Hillier et al. (Mar. 1995).
Genbank Report, Accession No. H93538, Hillier et al. (Dec. 1995).
Genbank Report, Accession No. T40526, Hillier et al. (Jan. 1995).
Genbank Report, Accession No. AA135754, Hillier et al. (May 1997).
Genbank Report, Accession No. D62918, Fujiwara et al. (Aug. 1995).
Genbank Report, Accession No. R71091, Hillier et al. (Jun. 1995).
Genbank Report, Accession No. W69476, Hillier et al. (Jun. 1996).
Genbank Report, Accession No. AA081350, Hillier et al. (Oct. 1996).
Genbank Report, Accession No. H72343, Hillier et al. (Oct. 1995).
Genbank Report, Accession No. D62168, Fujiwara et al. (Aug. 1995).
Genbank Report, Accession No. T96904, Hillier et al. (Mar. 1995).
Genbank Report, Accession No. T39345, Hillier et al. (Jan. 1995).
Genbank Report, Accession No. R81660, Hillier et al. (Jun. 1995).
Genbank Report, Accession No. R24376, Hillier et al. (Apr. 1995).
Genbank Report, Accession No. R96867, Hillier et al. (Sep. 1995).
Arch, R. et al., "Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44," Science 257:682-685 (1992).
Aruffo, A. et al., "CD44 Is the Principal Cell Surface Receptor for Hyaluronate," Cell 61:1303-1313 (1990).
Biocentury, The Bernstein Report on BioBusiness, Jan. 29, 1996.
Carter, W.G. and Wayner, E.A., "Characterization of the Class III Collagen Receptor, a Phosphorylated, Transmembrane Glycoprotein Expressed in Nucleated Human Cells," J. Bio. Chem. 263:4193-4201 (1988).
East,J.A. and Hart, I.R., "CD44 and its Role in Tumour Progression and Metastasis," Eur. J. Cancer 29A(14):1921-1922 (1993).
Goldstein, L.A. et al., "A Human Lymphocyte Homing Receptor, the Hermes Antigen, Is Related to Cartilage Proteoglycan Core and Link Proteins," Cell 56:1063-1072 (1989).
Gunthert, U. et al., "A New Variant of Glycoprotein CD44 Confers Metastatic Potential to Rat Carcinoma Cells," Cell 65:13-24 (1991).
Gyuris, J. et al., "Cdi1, a Human G1 and S Phase Protein Phosphatase That Associates with Cdk2," Cell 75:791-803 (1993).
Haynes, B.F. et al., "CD44 -- A molecule involved in leukocyte adherence and T-cell activation," Immunology Today 10:423-428 (1989).
Herrlich, P. et al., "CD44 splice variants: metastases meet lymphocytes," Immunology Today 14(8):395-399 (1993).
Jain, M. et al., "Role of CD44 in the Reaction of Vascular Smooth Muscle Cells to Arterial Wall Injury," J. Clin. Invest. 97(3):596-603 (Feb. 1996).
Jalkanen, S. et al., "Lymphocyte Recognition of High Endothelium: Antibodies to Distinct Epitopes of an 85-90-kD Glycoprotein Antigen Differentially Inhibit Lymphocyte Binding to Lymph Node, Mucosal, or Synovial Endothelial Cells," J. Cell Bio. 105:983-990 (1987).
Jalkanen, S. et al., "Biochemical Properties of Glycoproteins Involved in Lymphocyte Recognition of High Endothelial Venules In Man," J. Immuno. 141:1615-1623 (1988).
Lazaar, A.L. et al., "T Lymphocytes Adhere to Airway Smooth Muscle Cells Via Integrins and CD44 and Induce Smooth Muscle Cell DNA Synthesis," J. Exp. Med. 180:807-816 (1994).
Lesley, J. et al., "CD44 and Its Interaction with Extracellular Matrix," Adv. Immuno. 54:271-335 (1993).
Mackay, C.R. et al., "Expression and Modulation of CD44 Variant Isoforms in Humans," J. Cell Bio. 124(1&2):71-82 (1994).
Masellis-Smith, A. et al., "Hyaluronan-Dependent Motility of B Cells and Leukemic Plasma Cells in Blood, But Not of Bone Marrow Plasma Cells, in Multiple Myeloma: Alternative Use of Receptor for Hyaluronan-Mediated Motility (RHAMM) and CD44," Blood 87(5):1891-1899 (Mar. 1996).
Miyake, K. et al., "Monoclonal Antibodies to Pgp-1/CD44 Block Lympho-Hemopoiesis in Long-term Bone Marrow Cultures," J. Exp. Med. 171:477-488 (1990).
Miyake, K. et al., "Hyaluronate Can Function as a Cell Adhesion Molecule and CD44 Participates in Hyaluronate Recognition," J. Exp. Med. 172:69-75 (1990).
Moll, J. et al., "Accelerated Immune Response in Transgenic Mice Expressing Rat CD44v4-v7 on T Cells," J. Immuno. 156:2085-2094 (Mar. 1996).
Okada, H. et al., "Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells," Cancer Immunol. Immunother. 39:313-317 (1994).
Ruiz, P. et al., "CD44 isoforms during differentiation and development," BioEssays 17(1):17-24 (1995).
Screaton, G.R. et al., "The Identification of a New Alternative Exon with Highly Restricted Tissue Expression in Transcripts Encoding the Mouse Pgp-1 (CD44) Homing Receptor," J. Bio. Chem. 268(17):12235-12238 (1993).
Telen, M.J. et al., "A Blood Group-related Polymorphism of CD44 Abolishes A Hyaluronan-binding Consensus Sequence without Preventing Hyaluronan Binding," J. Bio. Chem. 271(12):7147-7153 (Mar. 1996).
Webb, D.S.A. et al., "LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release," Science 249:1295-1297 (1990).
Weber, G.F. et al., "Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)," Science 271:509-512 (Jan. 1996).
Yang, B. et al., "Identification of Two Hyaluronan-binding Domains in the Hyaluronan Receptor RHAMM," J. Bio. Chem. 268(12):8617-8623 (1993).

Affiliated with

Also associated with

Rating

CD44-like protein and nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with CD44-like protein and nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CD44-like protein and nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-465672