CD40-interacting and TRAF-interacting proteins

Details CD40-interacting and TRAF-interacting proteins CD40-interacting and TRAF-interacting proteins

2006-08-29

2006-08-29

Weber, Jon (Department: 1653)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S320100, C530S351000

Reexamination Certificate

active

07098322

ABSTRACT:
The present invention relates to novel proteins interacting with the cytoplasmic domain of CD40, which are useful in the treatment of CD40 and/or NF-κB related diseases. Surprisingly, these proteins do not show significant amino acid sequence identity with the members of tumor necrosis factor receptor associated factor (TRAF) family; and thus, offer the possibility to modulate the CD40 and/or NF-κB signaling pathway independently from interaction of TRAF with CD40.

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