CD40-binding activating antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S130100, C424S133100, C424S141100, C424S143100, C424S144100, C424S173100, C435S326000, C435S328000, C435S332000, C435S334000, C435S343000, C435S343100, C435S346000, C530S387100, C530S387300, C530S388200, C530S388220, C530S388700

Reexamination Certificate

active

07547438

ABSTRACT:
Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

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