CD4+ T-lymphocyte-specific hepatitis C virus epitopes

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S184100, C424S185100, C424S186100, C424S228100, C424S278100, C530S300000, C514S002600

Reexamination Certificate

active

10962145

ABSTRACT:
The invention relates to hepatitis C virus epitopes which are CD4+T-lymphocyte specific, and to vaccines containing these epitopes.

REFERENCES:
patent: 5980899 (1999-11-01), Berzofsky et al.
patent: 6007982 (1999-12-01), Deleys et al.
patent: 6027729 (2000-02-01), Houghton et al.
patent: 6183949 (2001-02-01), Seidel et al.
patent: 6221355 (2001-04-01), Dowdy
patent: 6689363 (2004-02-01), Sette et al.
patent: 2003/0186224 (2003-10-01), Gerlach et al.
patent: 0 501 557 (1992-09-01), None
patent: 0 518 313 (1992-12-01), None
patent: WO 01/68820 (2001-09-01), None
patent: WO 01/21189 (2001-03-01), None
patent: WO 01/90197 (2001-11-01), None
patent: WO 02/04484 (2002-01-01), None
patent: WO 02/26785 (2002-04-01), None
Bowie et al., Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions, Science, vol. 247 No. 4948, pp. 1306-1310 (Mar. 1990).
Diepolder et al., The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis, Journal of Molecular Medicine, vol. 74 No. 10, pp. 583-588 (Oct. 1996).
Lauer et al., Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities, Journal of Virology, vol. 76 No. 12, pp. 6104-6113 (Jun. 2002).
LeRoux-Roels, Development of prophylactic and therapeutic vaccines against hepatitis C virus, Expert Review of Vaccines, vol. 4 No. 3, pp. 351-371 (Jun. 2005).
Schulze zur Wiesch et al., Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes, Journal of Immunology, vol. 175 No. 6, pp. 36.3-3613 (Sep. 2005).
Shirai et al., Induction of cytotoxic T cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein, Journal of Virology, vol. 66 No. 7, pp. 4098-4106 (Jul. 1992).
Schirren et al., Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation . . . , Journal of Hepatology, vol. 39 No. 3, pp. 397-404 (Sep. 2003).
Uno-Furuta et al.. Inducation of virus-specific cytotoxic T lymphocytes by in vivo electric administration of peptides, Vaccine, vol. 19 Nos. 15-16, pp. 2190-2196 (Feb 2001).
Takamizawa et al., “Structure and organization of the hepatitis C virus genome isolated from human carriers,” Journal of Virology, vol. 65 No. 3, pp. 1105-1113 (Mar. 1991).
Trowbidge, R. et al., “Molecular clonging of an Australian isolate of hepatitis C virus”, Arch. Virol, vol. 143(3), (1998), pp. 501-511, no date available.
Takamizawa, A et al., “Structure and organization of the hepatitis C virus genome isolated from human carriers”, J. Virol, vol. 65(3), (1991), pp. 1105-1113, no date available.
Yanagi, M., et al., “Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of chimpanzee”, Proc. Natl. Acad. Sci. U.S.A. vol. 94(16), (1997), pp. 8738-8743, no date available.
Okamoto, H., et al., “Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human”, J. Gen. Virol., vol. 72(Pt 11), (1991), pp. 2697-2704, no date available.
Okamoto, H., et al., “Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes”, Virology, vol. 188(1), (1992), pp. 331-341, no date available.
Choo, Q.L., et al., “Genetic organization and diversity of the hepatitis C virus”, Proc. Natl. Acad. Sci. U.S.A., vol. 88(6), (1991), pp. 2451-2455, no date available.
Tanaka, T., et al., “Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals”, Virus Res. vol. 23(1-2), (1992), pp. 39-53, no date available.
Kato, N., et al., “Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis”, Proc. Natl. Acad. Sci. U.S.A. vol 87(24), (1990), pp. 9524-9528, no date available.
Chen, P.J., et al., “The Taiwanese hepatitis C virus genome”: sequence determination and mapping the 5′termini of viral genomic and antigenomic RNA, Virology, vol. 188(1), (1992), pp. 102-113, no date available.
Inchauspe, G., et al., “Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates”, Proc. Natl. Acad. Sci. U.S.A., vol. 88(22) (1991), pp. 10292-10296, no date available.
Chayama, K., “Toranomon Hospital, Department of Gastroenterology”; 2-2-2 Toranomon, Minato-ku, Tokyo 105, Japan: “Direct Submission”, Submitted (Feb. 18, 1995) to the DDBJ/EMBL/GenBank databases; Comment: D26556: Submitted (Jan. 20, 1994) to DDBJ by: Kazuaki Chayama.
Chamberlain, R.W., et al., “Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East”, J. Gen Virol., vol. 78(Pt 6), (1997), pp. 1341-1347, no date available.
Chamberlain, R.W., et al., “The complete coding sequence of hepatitis C virus genotype 5a, the predominant genotype in South Africa”, Biochem. Biophys. Res. Commun., vol. 236(1), (Jul. 1997), pp. 44-49.
Adams, N.J., et al., “Complete coding sequence of hepatitis C virus genotype 6a”, Biochem. Biophys. Res. Commun., vol. 234(2), (1997), pp. 393-396, no date available.
Honda, M., et al., “Sequence comparisons for a hepatitis C virus genome RNA isolated from a patient with liver cirrhosis”, Gene, vol. 120(2), (1992), pp. 317-318, no date available.
Okamoto, H., et al., “Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability”, Virology, vol. 190(2), (1992), pp. 894-899, no date available.
Choo, Q.L., et al., “Isolation of a cDNA clone derived from a blood-bome non-A, non-B viral hepatitis genome”, Science, vol. 244(4902), (Apr. 21, 1989), pp. 359-362.
“Primary consensus sequence complete 1b genomes available in EMBL database”, (Jan. 2000).
Diepolder, et al., “Immunodominant CD4+ T-Cell Epitope within Nonstructural Protein 3 in Acute Hepatitis C Virus Infection”, Journal of Virology, (Aug. 1997), pp. 6011-6019.
Khudyakov, Yu. E., et al., “Linear B-cell epitopes of the NS3-NS4-NS5 proteins of the hepatitis C virus as modelled with synthetic peptides”, Virology, vol. 206(1), (1995), pp. 666-672, no date available.
Qi Z, et al., “Clone Q379 immunoscreened from a Chinese HCV cDNA lambda gt11 library”, Current Microbiology, United States, Bd. 28, No. 3, (Mar. 1994), pp. 161-163.
Ramsay, A.J., et al., “DNA vaccination against virus infection and enhancement of antiviral immunity following consecutive immunization with DNA and viral vectors”, Immunology and Cell Biology, vol. 75, (1997), pp. 382-388, no date available.
Database TREMBL ′online!; Polyprotein (Fragment) fromHepatitis C virus, (Nov. 1, 1996) , retrieved from EBI; Database accession No. q68529; XP002208337, abstract, no date available.

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